Abstract
We investigated the in vivo effects of rufloxacin and ciprofloxacin on T-cell subsets and tumor necrosis factor production in mice infected with Bacteroides fragilis. These quinolones did not alter the helper/suppressor ratio but did modulate the kinetics of tumor necrosis factor production in infected animals. This result correlated with the observed therapeutic efficacies of the quinolones.
Full text
PDF![1711](https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c30/188049/0324bba06970/aac00030-0167.png)
![1712](https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c30/188049/f8e054f41eb9/aac00030-0168.png)
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Forsgren A., Schlossman S. F., Tedder T. F. 4-Quinolone drugs affect cell cycle progression and function of human lymphocytes in vitro. Antimicrob Agents Chemother. 1987 May;31(5):768–773. doi: 10.1128/aac.31.5.768. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Gollapudi S. V., Gupta A., Thadepalli H., Perez A. Use of lymphokines in treatment of experimental intra-abdominal abscess caused by Bacteroides fragilis. Infect Immun. 1988 Sep;56(9):2369–2372. doi: 10.1128/iai.56.9.2369-2372.1988. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Gollapudi S. V., Kern M. A novel mitogen released by lipid A-stimulated bone marrow cells. J Immunol. 1982 May;128(5):2206–2208. [PubMed] [Google Scholar]
- Gollapudi S. V., Vayuvegula B., Gupta S., Fok M., Thadepalli H. Aryl-fluoroquinolone derivatives A-56619 (difloxacin) and A-56620 inhibit mitogen-induced human mononuclear cell proliferation. Antimicrob Agents Chemother. 1986 Sep;30(3):390–394. doi: 10.1128/aac.30.3.390. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Imbimbo B. P., Broccali G., Cesana M., Crema F., Attardo-Parrinello G. Inter- and intrasubject variabilities in the pharmacokinetics of rufloxacin after single oral administration to healthy volunteers. Antimicrob Agents Chemother. 1991 Feb;35(2):390–393. doi: 10.1128/aac.35.2.390. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Riesbeck K., Andersson J., Gullberg M., Forsgren A. Fluorinated 4-quinolones induce hyperproduction of interleukin 2. Proc Natl Acad Sci U S A. 1989 Apr;86(8):2809–2813. doi: 10.1073/pnas.86.8.2809. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Roche Y., Fay M., Gougerot-Pocidalo M. A. Enhancement of interleukin 2 production by quinolone-treated human mononuclear leukocytes. Int J Immunopharmacol. 1988;10(2):161–167. doi: 10.1016/0192-0561(88)90091-4. [DOI] [PubMed] [Google Scholar]
- Roche Y., Fay M., Gougerot-Pocidalo M. A. Interleukin-1 production by antibiotic-treated human monocytes. J Antimicrob Chemother. 1988 May;21(5):597–607. doi: 10.1093/jac/21.5.597. [DOI] [PubMed] [Google Scholar]
- Shapiro M. E., Kasper D. L., Zaleznik D. F., Spriggs S., Onderdonk A. B., Finberg R. W. Cellular control of abscess formation: role of T cells in the regulation of abscesses formed in response to Bacteroides fragilis. J Immunol. 1986 Jul 1;137(1):341–346. [PubMed] [Google Scholar]
- Shapiro M. E., Onderdonk A. B., Kasper D. L., Finberg R. W. Cellular immunity to Bacteroides fragilis capsular polysaccharide. J Exp Med. 1982 Apr 1;155(4):1188–1197. doi: 10.1084/jem.155.4.1188. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Thadepalli H., Gollapudi S. V., Chuah S. K. Therapeutic evaluation of difloxacin (A-56619) and A-56620 for experimentally induced Bacteroides fragilis-associated intra-abdominal abscess. Antimicrob Agents Chemother. 1986 Oct;30(4):574–576. doi: 10.1128/aac.30.4.574. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Thadepalli H., Hajji M., Perumal V. K., Chuah S. K., Gollapudi S. Evaluation of temafloxacin in a rat model of intra-abdominal abscess. J Antimicrob Chemother. 1992 Jun;29(6):687–692. doi: 10.1093/jac/29.6.687. [DOI] [PubMed] [Google Scholar]
- Zaleznik D. F., Finberg R. W., Shapiro M. E., Onderdonk A. B., Kasper D. L. A soluble suppressor T cell factor protects against experimental intraabdominal abscesses. J Clin Invest. 1985 Mar;75(3):1023–1027. doi: 10.1172/JCI111763. [DOI] [PMC free article] [PubMed] [Google Scholar]