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. 1993 Aug;37(8):1713–1716. doi: 10.1128/aac.37.8.1713

Activity of cationically substituted bis-benzimidazoles against experimental Pneumocystis carinii pneumonia.

R R Tidwell 1, S K Jones 1, N A Naiman 1, L C Berger 1, W B Brake 1, C C Dykstra 1, J E Hall 1
PMCID: PMC188050  PMID: 8215291

Abstract

On the basis of a previously observed correlation between the antimicrobial activity and DNA binding strength of dicationic molecules, a series of 10 dicationically substituted bis-benzimidazoles were tested for activity in the rat model of Pneumocystis carinii pneumonia. One of the compounds, 1,4-bis[5-(2-imidazolinyl)-2-benzimidazolyl]butane, was found to be more potent and less toxic than pentamidine.

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Selected References

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