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. 1989 Dec;135(6):977–987.

Molecular genetic analysis of lymphoid tumors arising after organ transplantation.

J Locker 1, M Nalesnik 1
PMCID: PMC1880507  PMID: 2556930

Abstract

A variety of gene analyses were performed on lymphoid tumors from transplant patients who received cyclosporine A for immunosuppression. Epstein-Barr virus DNA was detected in the tumors, and the structure of circular episomal virus DNA was used as a measure of cell clonality. This analysis was correlated with clonality determined by study of immunoglobulin gene rearrangement. Some of the tumors had DNA rearrangements near the c-myc gene. Analysis suggested the pathogenesis of the tumors and indicated four categories of lymphoproliferation, three neoplastic and one reactive.

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Selected References

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