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. 1993 Sep;37(9):1737–1741. doi: 10.1128/aac.37.9.1737

Microbial conversion of avermectins by Saccharopolyspora erythraea: glycosylation at C-4' and C-4''.

M Schulman 1, P Doherty 1, B Arison 1
PMCID: PMC188062  PMID: 8239577

Abstract

Avermectins and ivermectins are glycosylated at C-4'' and C-4' by both growing and resting cells of Saccharopolyspora erythraea. The reaction is catalyzed by a glycosyltransferase which is constitutive. The enzyme uses UDP-glucose as the glycosyl donor and avermectin or ivermectin mono- and disaccharides as acceptors. Avermectin and ivermectin aglycones and erythromycin A are not substrates for the enzyme.

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Selected References

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