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. 1992 Jan 11;304(6819):80–83. doi: 10.1136/bmj.304.6819.80

Alcohol consumption and its relation to cardiovascular risk factors in British women.

G Razay 1, K W Heaton 1, C H Bolton 1, A O Hughes 1
PMCID: PMC1881014  PMID: 1737144

Abstract

OBJECTIVE--To examine the relation between alcohol consumption and risk factors for coronary heart disease in women. DESIGN--Cross sectional study of a stratified random sample of the population grouped into five categories of habitual alcohol consumption. SETTING--People registered with general practitioners at two large health centres in east Bristol, England. SUBJECTS--1048 women aged 25-69 years. MAIN OUTCOME MEASURES--Fasting plasma concentrations of insulin, total cholesterol, total triglycerides, and high density lipoprotein cholesterol, including its subfractions HDL2 and HDL3, and body mass index. RESULTS--Compared with non-drinkers women consuming a moderate amount of alcohol (1-20 g/day) had lower plasma concentrations of triglycerides, by 0.19 mmol/l (95% confidence interval 0.07 to 0.35); cholesterol, by 0.4 mmol/l (0.19 to 0.61); and insulin, by 1.4 mU/l (0.43 to 1.97) and a lower body mass index, by 1.2 kg/m2 (0.43 to 1.97). They also had higher concentrations of high density lipoprotein cholesterol, by 0.09 mmol/l (0.03 to 0.15); HDL2 cholesterol by 0.05 mmol/l (-0.02 to 0.10) and HDL3 cholesterol, by 0.06 mmol/l (0.06 to 0.11). All these were independent of body mass index, smoking habits, and taking oral contraceptives. CONCLUSIONS--Moderate alcohol consumption is associated with lower levels of cardiovascular risk factors in women. Insulin may have a central role.

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Selected References

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  1. Ballantyne F. C., Clark R. S., Simpson H. S., Ballantyne D. High density and low density lipoprotein subfractions in survivors of myocardial infarction and in control subjects. Metabolism. 1982 May;31(5):433–437. doi: 10.1016/0026-0495(82)90230-x. [DOI] [PubMed] [Google Scholar]
  2. Belfrage P., Berg B., Hägerstrand I., Nilsson-Ehle P., Tornqvist H., Wiebe T. Alterations of lipid metabolism in healthy volunteers during long-term ethanol intake. Eur J Clin Invest. 1977 Apr;7(2):127–131. doi: 10.1111/j.1365-2362.1977.tb01584.x. [DOI] [PubMed] [Google Scholar]
  3. Castelli W. P., Doyle J. T., Gordon T., Hames C. G., Hjortland M. C., Hulley S. B., Kagan A., Zukel W. J. Alcohol and blood lipids. The cooperative lipoprotein phenotyping study. Lancet. 1977 Jul 23;2(8030):153–155. doi: 10.1016/s0140-6736(77)90176-3. [DOI] [PubMed] [Google Scholar]
  4. Criqui M. H., Cowan L. D., Tyroler H. A., Bangdiwala S., Heiss G., Wallace R. B., Cohn R. Lipoproteins as mediators for the effects of alcohol consumption and cigarette smoking on cardiovascular mortality: results form the Lipid Research Clinics Follow-up Study. Am J Epidemiol. 1987 Oct;126(4):629–637. doi: 10.1093/oxfordjournals.aje.a114702. [DOI] [PubMed] [Google Scholar]
  5. Diehl A. K., Fuller J. H., Mattock M. B., Salter A. M., el-Gohari R., Keen H. The relationship of high density lipoprotein subfractions to alcohol consumption, other lifestyle factors, and coronary heart disease. Atherosclerosis. 1988 Feb;69(2-3):145–153. doi: 10.1016/0021-9150(88)90008-1. [DOI] [PubMed] [Google Scholar]
  6. Dietschy J. M., Brown M. S. Effect of alterations of the specific activity of the intracellular acetyl CoA pool on apparent rates of hepatic cholesterogenesis. J Lipid Res. 1974 Sep;15(5):508–516. [PubMed] [Google Scholar]
  7. Ducimetiere P., Eschwege E., Papoz L., Richard J. L., Claude J. R., Rosselin G. Relationship of plasma insulin levels to the incidence of myocardial infarction and coronary heart disease mortality in a middle-aged population. Diabetologia. 1980 Sep;19(3):205–210. doi: 10.1007/BF00275270. [DOI] [PubMed] [Google Scholar]
  8. Evans S. J. Good surveys guide. BMJ. 1991 Feb 9;302(6772):302–303. doi: 10.1136/bmj.302.6772.302. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Fehily A. M., Yarnell J. W., Bolton C. H., Butland B. K. Dietary determinants of plasma lipids and lipoproteins: the Caerphilly Study. Eur J Clin Nutr. 1988 May;42(5):405–413. [PubMed] [Google Scholar]
  10. Gordon T., Kannel W. B. Drinking habits and cardiovascular disease: the Framingham Study. Am Heart J. 1983 Apr;105(4):667–673. doi: 10.1016/0002-8703(83)90492-1. [DOI] [PubMed] [Google Scholar]
  11. Haffner S. M., Applebaum-Bowden D., Wahl P. W., Hoover J. J., Warnick G. R., Albers J. J., Hazzard W. R. Epidemiological correlates of high density lipoprotein subfractions, apolipoproteins A-I, A-II, and D, and lecithin cholesterol acyltransferase. Effects of smoking, alcohol, and adiposity. Arteriosclerosis. 1985 Mar-Apr;5(2):169–177. doi: 10.1161/01.atv.5.2.169. [DOI] [PubMed] [Google Scholar]
  12. Haskell W. L., Camargo C., Jr, Williams P. T., Vranizan K. M., Krauss R. M., Lindgren F. T., Wood P. D. The effect of cessation and resumption of moderate alcohol intake on serum high-density-lipoprotein subfractions. A controlled study. N Engl J Med. 1984 Mar 29;310(13):805–810. doi: 10.1056/NEJM198403293101301. [DOI] [PubMed] [Google Scholar]
  13. Heaton K. W., Braddon F. E., Mountford R. A., Hughes A. O., Emmett P. M. Symptomatic and silent gall stones in the community. Gut. 1991 Mar;32(3):316–320. doi: 10.1136/gut.32.3.316. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Jackson R., Scragg R., Beaglehole R. Alcohol consumption and risk of coronary heart disease. BMJ. 1991 Jul 27;303(6796):211–216. doi: 10.1136/bmj.303.6796.211. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Jacobs D. R., Jr, Mebane I. L., Bangdiwala S. I., Criqui M. H., Tyroler H. A. High density lipoprotein cholesterol as a predictor of cardiovascular disease mortality in men and women: the follow-up study of the Lipid Research Clinics Prevalence Study. Am J Epidemiol. 1990 Jan;131(1):32–47. doi: 10.1093/oxfordjournals.aje.a115483. [DOI] [PubMed] [Google Scholar]
  16. Marmot M. G., Rose G., Shipley M. J., Thomas B. J. Alcohol and mortality: a U-shaped curve. Lancet. 1981 Mar 14;1(8220 Pt 1):580–583. doi: 10.1016/s0140-6736(81)92032-8. [DOI] [PubMed] [Google Scholar]
  17. Miller G. J., Miller N. E. Plasma-high-density-lipoprotein concentration and development of ischaemic heart-disease. Lancet. 1975 Jan 4;1(7897):16–19. doi: 10.1016/s0140-6736(75)92376-4. [DOI] [PubMed] [Google Scholar]
  18. Miller N. E., Bolton C. H., Hayes T. M., Bainton D., Yarnell J. W., Baker I. A., Sweetnam P. M. Associations of alcohol consumption with plasma high density lipoprotein cholesterol and its major subfractions: the Caerphilly and Speedwell Collaborative Heart Disease Studies. J Epidemiol Community Health. 1988 Sep;42(3):220–225. doi: 10.1136/jech.42.3.220. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Miller N. E., Hammett F., Saltissi S., Rao S., van Zeller H., Coltart J., Lewis B. Relation of angiographically defined coronary artery disease to plasma lipoprotein subfractions and apolipoproteins. Br Med J (Clin Res Ed) 1981 May 30;282(6278):1741–1744. doi: 10.1136/bmj.282.6278.1741. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Oehler G., Bleyl H., Matthes K. J. Hyperinsulinemia in hepatic steatosis. Int J Obes. 1982;6 (Suppl 1):137–144. [PubMed] [Google Scholar]
  21. Oettlé G. J., Emmett P. M., Heaton K. W. Glucose and insulin responses to manufactured and whole-food snacks. Am J Clin Nutr. 1987 Jan;45(1):86–91. doi: 10.1093/ajcn/45.1.86. [DOI] [PubMed] [Google Scholar]
  22. Patel D. G., Singh S. P. Effect of ethanol and its metabolites on glucose mediated insulin release from isolated islets of rats. Metabolism. 1979 Jan;28(1):85–89. doi: 10.1016/0026-0495(79)90173-2. [DOI] [PubMed] [Google Scholar]
  23. Pyöräla K. Relationship of glucose tolerance and plasma insulin to the incidence of coronary heart disease: results from two population studies in Finland. Diabetes Care. 1979 Mar-Apr;2(2):131–141. doi: 10.2337/diacare.2.2.131. [DOI] [PubMed] [Google Scholar]
  24. Stampfer M. J., Colditz G. A., Willett W. C., Speizer F. E., Hennekens C. H. A prospective study of moderate alcohol consumption and the risk of coronary disease and stroke in women. N Engl J Med. 1988 Aug 4;319(5):267–273. doi: 10.1056/NEJM198808043190503. [DOI] [PubMed] [Google Scholar]
  25. Taskinen M. R., Välimäki M., Nikkilä E. A., Kuusi T., Ehnholm C., Ylikahri R. High density lipoprotein subfractions and postheparin plasma lipases in alcoholic men before and after ethanol withdrawal. Metabolism. 1982 Nov;31(11):1168–1174. doi: 10.1016/0026-0495(82)90169-x. [DOI] [PubMed] [Google Scholar]
  26. Thornton J., Symes C., Heaton K. Moderate alcohol intake reduces bile cholesterol saturation and raises HDL cholesterol. Lancet. 1983 Oct 8;2(8354):819–822. doi: 10.1016/s0140-6736(83)90738-9. [DOI] [PubMed] [Google Scholar]
  27. Welborn T. A., Wearne K. Coronary heart disease incidence and cardiovascular mortality in Busselton with reference to glucose and insulin concentrations. Diabetes Care. 1979 Mar-Apr;2(2):154–160. doi: 10.2337/diacare.2.2.154. [DOI] [PubMed] [Google Scholar]
  28. Willett W. C., Stampfer M. J., Colditz G. A., Rosner B. A., Hennekens C. H., Speizer F. E. Moderate alcohol consumption and the risk of breast cancer. N Engl J Med. 1987 May 7;316(19):1174–1180. doi: 10.1056/NEJM198705073161902. [DOI] [PubMed] [Google Scholar]

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