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. 1993 Sep;37(9):2003–2006. doi: 10.1128/aac.37.9.2003

Detection and characterization of mupirocin resistance in Staphylococcus aureus.

D A Janssen 1, L T Zarins 1, D R Schaberg 1, S F Bradley 1, M S Terpenning 1, C A Kauffman 1
PMCID: PMC188110  PMID: 8239621

Abstract

Fourteen mupirocin-resistant Staphylococcus aureus strains were isolated over 18 months; 12 exhibited low-level resistance, while two showed high-level resistance. Highly mupirocin-resistant strains contained a large plasmid which transferred mupirocin resistance to other S. aureus strains and to Staphylococcus epidermidis. This plasmid and pAM899-1, a self-transferable gentamicin resistance plasmid, have molecular and biologic similarities.

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Selected References

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  1. Barrett S. P. The value of nasal mupirocin in containing an outbreak of methicillin-resistant Staphylococcus aureus in an orthopaedic unit. J Hosp Infect. 1990 Feb;15(2):137–142. doi: 10.1016/0195-6701(90)90122-5. [DOI] [PubMed] [Google Scholar]
  2. Casewell M. W., Hill R. L. Mupirocin ('pseudomonic acid')--a promising new topical antimicrobial agent. J Antimicrob Chemother. 1987 Jan;19(1):1–5. doi: 10.1093/jac/19.1.1. [DOI] [PubMed] [Google Scholar]
  3. Cederna J. E., Terpenning M. S., Ensberg M., Bradley S. F., Kauffman C. A. Staphylococcus aureus nasal colonization in a nursing home: eradication with mupirocin. Infect Control Hosp Epidemiol. 1990 Jan;11(1):13–16. doi: 10.1086/646072. [DOI] [PubMed] [Google Scholar]
  4. Cookson B. D., Farrelly H., Stapleton P., Garvey R. P., Price M. R. Transferable resistance to triclosan in MRSA. Lancet. 1991 Jun 22;337(8756):1548–1549. doi: 10.1016/0140-6736(91)93242-2. [DOI] [PubMed] [Google Scholar]
  5. Cookson B. D. Mupirocin resistance in staphylococci. J Antimicrob Chemother. 1990 Apr;25(4):497–501. doi: 10.1093/jac/25.4.497. [DOI] [PubMed] [Google Scholar]
  6. Dyke K. G., Curnock S. P., Golding M., Noble W. C. Cloning of the gene conferring resistance to mupirocin in Staphylococcus aureus. FEMS Microbiol Lett. 1991 Jan 15;61(2-3):195–198. doi: 10.1016/0378-1097(91)90550-t. [DOI] [PubMed] [Google Scholar]
  7. Forbes B. A., Schaberg D. R. Transfer of resistance plasmids from Staphylococcus epidermidis to Staphylococcus aureus: evidence for conjugative exchange of resistance. J Bacteriol. 1983 Feb;153(2):627–634. doi: 10.1128/jb.153.2.627-634.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Fuchs P. C., Jones R. N., Barry A. L. Interpretive criteria for disk diffusion susceptibility testing of mupirocin, a topical antibiotic. J Clin Microbiol. 1990 Mar;28(3):608–609. doi: 10.1128/jcm.28.3.608-609.1990. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Hill R. L., Duckworth G. J., Casewell M. W. Elimination of nasal carriage of methicillin-resistant Staphylococcus aureus with mupirocin during a hospital outbreak. J Antimicrob Chemother. 1988 Sep;22(3):377–384. doi: 10.1093/jac/22.3.377. [DOI] [PubMed] [Google Scholar]
  10. Kauffman C. A., Terpenning M. S., He X., Zarins L. T., Ramsey M. A., Jorgensen K. A., Sottile W. S., Bradley S. F. Attempts to eradicate methicillin-resistant Staphylococcus aureus from a long-term-care facility with the use of mupirocin ointment. Am J Med. 1993 Apr;94(4):371–378. doi: 10.1016/0002-9343(93)90147-h. [DOI] [PubMed] [Google Scholar]
  11. Macrina F. L., Wood P. H., Jones K. R. Simple method for demonstrating small plasmid deoxyribonucleic acid molecules in oral streptococci. Appl Environ Microbiol. 1980 May;39(5):1070–1073. doi: 10.1128/aem.39.5.1070-1073.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Mupirocin-resistant Staphylococcus aureus. Lancet. 1987 Aug 15;2(8555):387–388. [PubMed] [Google Scholar]
  13. Rahman M., Connolly S., Noble W. C., Cookson B., Phillips I. Diversity of staphylococci exhibiting high-level resistance to mupirocin. J Med Microbiol. 1990 Oct;33(2):97–100. doi: 10.1099/00222615-33-2-97. [DOI] [PubMed] [Google Scholar]
  14. Rahman M., Noble W. C., Cookson B. Transmissible mupirocin resistance in Staphylococcus aureus. Epidemiol Infect. 1989 Apr;102(2):261–270. doi: 10.1017/s0950268800029939. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Reagan D. R., Doebbeling B. N., Pfaller M. A., Sheetz C. T., Houston A. K., Hollis R. J., Wenzel R. P. Elimination of coincident Staphylococcus aureus nasal and hand carriage with intranasal application of mupirocin calcium ointment. Ann Intern Med. 1991 Jan 15;114(2):101–106. doi: 10.7326/0003-4819-114-2-101. [DOI] [PubMed] [Google Scholar]
  16. Schaberg D. R., Power G., Betzold J., Forbes B. A. Conjugative R plasmids in antimicrobial resistance of Staphylococcus aureus causing nosocomial infections. J Infect Dis. 1985 Jul;152(1):43–49. doi: 10.1093/infdis/152.1.43. [DOI] [PubMed] [Google Scholar]
  17. Scully B. E., Briones F., Gu J. W., Neu H. C. Mupirocin treatment of nasal staphylococcal colonization. Arch Intern Med. 1992 Feb;152(2):353–356. [PubMed] [Google Scholar]
  18. Smith G. E., Kennedy C. T. Staphylococcus aureus resistant to mupirocin. J Antimicrob Chemother. 1988 Jan;21(1):141–142. doi: 10.1093/jac/21.1.141. [DOI] [PubMed] [Google Scholar]
  19. Thornsberry C., McDougal L. K. Successful use of broth microdilution in susceptibility tests for methicillin-resistant (heteroresistant) staphylococci. J Clin Microbiol. 1983 Nov;18(5):1084–1091. doi: 10.1128/jcm.18.5.1084-1091.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Vandenbroucke-Grauls C. M., Frénay H. M., van Klingeren B., Savelkoul T. F., Verhoef J. Control of epidemic methicillin-resistant Staphylococcus aureus in a Dutch university hospital. Eur J Clin Microbiol Infect Dis. 1991 Jan;10(1):6–11. doi: 10.1007/BF01967090. [DOI] [PubMed] [Google Scholar]
  21. Wise R., Johnson J. Mupirocin resistance. Lancet. 1991 Aug 31;338(8766):578–578. doi: 10.1016/0140-6736(91)91148-n. [DOI] [PubMed] [Google Scholar]

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