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. 1993 Sep;37(9):2020–2023. doi: 10.1128/aac.37.9.2020

Novel, plasmid-encoded, TEM-derived extended-spectrum beta-lactamase in Klebsiella pneumoniae conferring higher resistance to aztreonam than to extended-spectrum cephalosporins.

G Arlet 1, M Rouveau 1, G Fournier 1, P H Lagrange 1, A Philippon 1
PMCID: PMC188114  PMID: 8239625

Abstract

A clinical isolate of Klebsiella pneumoniae was more resistant to aztreonam than to cefotaxime and ceftazidime. It produced a clavulanate-susceptible beta-lactamase with an isoelectric point of 6.3 which readily hydrolyzed penicillins, cefotaxime, and ceftazidime, but which hydrolyzed aztreonam poorly. The enzyme was encoded by a gene on a 15-kb plasmid; the gene hybridized with an intragenic DNA probe of blaTEM.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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