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. 1993 Sep;37(9):2027–2029. doi: 10.1128/aac.37.9.2027

Lincosamide antibiotics stimulate dissociation of peptidyl-tRNA from ribosomes.

J R Menninger 1, R A Coleman 1
PMCID: PMC188116  PMID: 8239627

Abstract

At nonpermissive temperatures the peptidyl-tRNA hydrolase of pth(Ts) bacterial mutants is inactivated, and cells accumulate peptidyl-tRNA and die. Doses of erythromycin, lincomycin, or clindamycin that inhibited the growth of antibiotic-hypersensitive DB-11 pth+ cells accelerated the killing of DB-11 pth(Ts) cells at nonpermissive temperatures. Erythromycin and lincomycin also stimulated the accumulation of peptidyl-tRNA. Lincomycin and clindamycin stimulated peptidyl-tRNA dissociation from ribosomes.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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