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. 1994 May;38(5):1169–1171. doi: 10.1128/aac.38.5.1169

In vitro activities of furoquinoline and acridone alkaloids against Plasmodium falciparum.

L K Basco 1, S Mitaku 1, A L Skaltsounis 1, N Ravelomanantsoa 1, F Tillequin 1, M Koch 1, J Le Bras 1
PMCID: PMC188171  PMID: 8067758

Abstract

The in vitro activities of furo[2,3b]quinoline and acridone alkaloids against Plasmodium falciparum were evaluated by an isotopic semimicrotest. A pyran ring in the furoquinoline nucleus and 2-O-pyranoglycoside and 2-nitro substituents in the acridone nucleus improved the antimalarial activities of the compounds. These findings provide a clue for further chemical modifications.

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Selected References

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