Abstract
This double-blind randomized study compared 3-day regimens of cefixime (400 mg once daily) and ofloxacin (200 mg twice a day) in the treatment of urinary tract infections in women. The respective clinical cure rates for the two groups of women were 89 and 92% after 7 days and 81 and 84% after 4 weeks. The respective microbiological cure rates (free of bacteriuria) for the two groups of women were 83 and 86% after 7 days and 77 and 80% after 28 days. A 3-day cefixime regimen seems to be as efficient as a 3-day ofloxacin regimen in the treatment of uncomplicated cystitis in women.
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Selected References
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- Faulkner R. D., Yacobi A., Barone J. S., Kaplan S. A., Silber B. M. Pharmacokinetic profile of cefixime in man. Pediatr Infect Dis J. 1987 Oct;6(10):963–970. doi: 10.1097/00006454-198710000-00035. [DOI] [PubMed] [Google Scholar]
- Garlando F., Rietiker S., Täuber M. G., Flepp M., Meier B., Lüthy R. Single-dose ciprofloxacin at 100 versus 250 mg for treatment of uncomplicated urinary tract infections in women. Antimicrob Agents Chemother. 1987 Feb;31(2):354–356. doi: 10.1128/aac.31.2.354. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Greenberg R. N., Reilly P. M., Luppen K. L., Weinandt W. J., Ellington L. L., Bollinger M. R. Randomized study of single-dose, three-day, and seven-day treatment of cystitis in women. J Infect Dis. 1986 Feb;153(2):277–282. doi: 10.1093/infdis/153.2.277. [DOI] [PubMed] [Google Scholar]
- Hooton T. M., Johnson C., Winter C., Kuwamura L., Rogers M. E., Roberts P. L., Stamm W. E. Single-dose and three-day regimens of ofloxacin versus trimethoprim-sulfamethoxazole for acute cystitis in women. Antimicrob Agents Chemother. 1991 Jul;35(7):1479–1483. doi: 10.1128/aac.35.7.1479. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Johnson J. R., Stamm W. E. Urinary tract infections in women: diagnosis and treatment. Ann Intern Med. 1989 Dec 1;111(11):906–917. doi: 10.7326/0003-4819-111-11-906. [DOI] [PubMed] [Google Scholar]
- Norrby S. R. Short-term treatment of uncomplicated lower urinary tract infections in women. Rev Infect Dis. 1990 May-Jun;12(3):458–467. doi: 10.1093/clinids/12.3.458. [DOI] [PubMed] [Google Scholar]
- Sandberg T., Henning C., Iwarson S., Paulsen O. Cefadroxil once daily for three or seven days versus amoxycillin for seven days in uncomplicated urinary tract infections in women. Scand J Infect Dis. 1985;17(1):83–87. doi: 10.3109/00365548509070425. [DOI] [PubMed] [Google Scholar]