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. 1994 May;38(5):1186–1189. doi: 10.1128/aac.38.5.1186

Rifampin for therapy of experimental pneumococcal meningitis in rabbits.

R Nau 1, K Kaye 1, M Sachdeva 1, E R Sande 1, M G Täuber 1
PMCID: PMC188176  PMID: 8067762

Abstract

Rifampin at a maximally effective dose was less active than ceftriaxone (both drugs at 10 mg/kg of body weight.h) in a rabbit model of pneumococcal meningitis (delta log10 CFU/ml.h, -0.40 +/- 0.13 versus -0.77 +/- 0.18; P < 0.01). The bactericidal activity of rifampin decreased at concentrations in cerebrospinal fluid greater than those that are clinically achievable, and use of rifampin in combination with ofloxacin had no synergistic or additive effect.

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Selected References

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