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. 1994 Jun;38(6):1416–1418. doi: 10.1128/aac.38.6.1416

Pharmacodynamic effects of subinhibitory concentrations of imipenem on Pseudomonas aeruginosa in an in vitro dynamic model.

F Maggiolo 1, A Taras 1, S Frontespezi 1, M C Legnani 1, M A Silanos 1, G Pravettoni 1, F Suter 1
PMCID: PMC188222  PMID: 8092847

Abstract

The postantibiotic effect (PAE), sub-MIC effect (SME), and postantibiotic sub-MIC effect (PASME) of imipenem on Pseudomonas aeruginosa were investigated with an in vitro dynamic model reproducing in vivo elimination kinetics of the antibiotic. The PASMEs were constantly longer than the corresponding SMEs, but differences between them were not statistically significant. Both PASMEs and SMEs were initially bactericidal and were significantly longer than PAEs. The mean values of both PASMEs and SMEs were over 12 h. SMEs appear to be more relevant for the bacterial growth kinetics than PAEs.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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