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. 1994 Nov;38(11):2648–2650. doi: 10.1128/aac.38.11.2648

Growth of Cryptococcus neoformans in presence of L-dopa decreases its susceptibility to amphotericin B.

Y Wang 1, A Casadevall 1
PMCID: PMC188256  PMID: 7872761

Abstract

Cryptococcus neoformans grown with L-dopa was melanized and was less susceptible to amphotericin B. The results suggest that in vivo and in vitro susceptibilities to amphotericin B may differ.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Brajtburg J., Powderly W. G., Kobayashi G. S., Medoff G. Amphotericin B: current understanding of mechanisms of action. Antimicrob Agents Chemother. 1990 Feb;34(2):183–188. doi: 10.1128/aac.34.2.183. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Chuck S. L., Sande M. A. Infections with Cryptococcus neoformans in the acquired immunodeficiency syndrome. N Engl J Med. 1989 Sep 21;321(12):794–799. doi: 10.1056/NEJM198909213211205. [DOI] [PubMed] [Google Scholar]
  3. Enochs W. S., Nilges M. J., Swartz H. M. A standardized test for the identification and characterization of melanins using electron paramagnetic resonance (EPR) spectroscopy. Pigment Cell Res. 1993 Mar;6(2):91–99. doi: 10.1111/j.1600-0749.1993.tb00587.x. [DOI] [PubMed] [Google Scholar]
  4. Hill H. Z. The function of melanin or six blind people examine an elephant. Bioessays. 1992 Jan;14(1):49–56. doi: 10.1002/bies.950140111. [DOI] [PubMed] [Google Scholar]
  5. Ikeda R., Jacobson E. S. Heterogeneity of phenol oxidases in Cryptococcus neoformans. Infect Immun. 1992 Sep;60(9):3552–3555. doi: 10.1128/iai.60.9.3552-3555.1992. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Jacobson E. S., Tinnell S. B. Antioxidant function of fungal melanin. J Bacteriol. 1993 Nov;175(21):7102–7104. doi: 10.1128/jb.175.21.7102-7104.1993. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Kwon-Chung K. J., Hill W. B., Bennett J. E. New, special stain for histopathological diagnosis of cryptococcosis. J Clin Microbiol. 1981 Feb;13(2):383–387. doi: 10.1128/jcm.13.2.383-387.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Kwon-Chung K. J., Polacheck I., Popkin T. J. Melanin-lacking mutants of Cryptococcus neoformans and their virulence for mice. J Bacteriol. 1982 Jun;150(3):1414–1421. doi: 10.1128/jb.150.3.1414-1421.1982. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Larsson B. S. Interaction between chemicals and melanin. Pigment Cell Res. 1993 Jun;6(3):127–133. doi: 10.1111/j.1600-0749.1993.tb00591.x. [DOI] [PubMed] [Google Scholar]
  10. MASON H. S., INGRAM D. J., ALLEN B. The free radical property of melanins. Arch Biochem Biophys. 1960 Feb;86:225–230. doi: 10.1016/0003-9861(60)90409-4. [DOI] [PubMed] [Google Scholar]
  11. Nurudeen T. A., Ahearn D. G. Regulation of melanin production by Cryptococcus neoformans. J Clin Microbiol. 1979 Nov;10(5):724–729. doi: 10.1128/jcm.10.5.724-729.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Polacheck I., Hearing V. J., Kwon-Chung K. J. Biochemical studies of phenoloxidase and utilization of catecholamines in Cryptococcus neoformans. J Bacteriol. 1982 Jun;150(3):1212–1220. doi: 10.1128/jb.150.3.1212-1220.1982. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Polacheck I., Platt Y., Aronovitch J. Catecholamines and virulence of Cryptococcus neoformans. Infect Immun. 1990 Sep;58(9):2919–2922. doi: 10.1128/iai.58.9.2919-2922.1990. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Ro J. Y., Lee S. S., Ayala A. G. Advantage of Fontana-Masson stain in capsule-deficient cryptococcal infection. Arch Pathol Lab Med. 1987 Jan;111(1):53–57. [PubMed] [Google Scholar]
  15. Shaw C. E., Kapica L. Production of diagnostic pigment by phenoloxidase activity of cryptococcus neoformans. Appl Microbiol. 1972 Nov;24(5):824–830. doi: 10.1128/am.24.5.824-830.1972. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Wang Y., Casadevall A. Susceptibility of melanized and nonmelanized Cryptococcus neoformans to nitrogen- and oxygen-derived oxidants. Infect Immun. 1994 Jul;62(7):3004–3007. doi: 10.1128/iai.62.7.3004-3007.1994. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Williamson P. R. Biochemical and molecular characterization of the diphenol oxidase of Cryptococcus neoformans: identification as a laccase. J Bacteriol. 1994 Feb;176(3):656–664. doi: 10.1128/jb.176.3.656-664.1994. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Zuger A., Louie E., Holzman R. S., Simberkoff M. S., Rahal J. J. Cryptococcal disease in patients with the acquired immunodeficiency syndrome. Diagnostic features and outcome of treatment. Ann Intern Med. 1986 Feb;104(2):234–240. doi: 10.7326/0003-4819-104-2-234. [DOI] [PubMed] [Google Scholar]

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