Abstract
OBJECTIVE--To investigate the risk of prostate, ovarian, and endometrial cancer among relatives of patients with breast cancer. DESIGN--Cohort study of 947 pedigrees in which the proband had breast cancer, linked with the Icelandic cancer registry. SETTING--Iceland. SUBJECTS--The 947 pedigrees included 29,725 people, of whom 1539 had breast cancer, 467 had prostate cancer, 135 ovarian cancer, and 105 endometrial cancer. MAIN OUTCOME MEASURES--Risk of prostate, ovarian, and endometrial cancer among blood relatives of women with breast cancer compared with risk in spouses. RESULTS--The risk of prostate cancer was significantly raised for all relatives (1.5), first degree relatives (1.4), and second degree relatives (1.3) of women with breast cancer. Risk of ovarian cancer was raised for all relatives (1.9) and first degree relatives (1.9) and risk of endometrial cancer was raised for all relatives only (1.9). The risk of prostate cancer was raised if the proband with breast cancer had a first degree relative with prostate cancer. CONCLUSIONS--Coaggregation exists between breast cancer and cancers of the prostate, ovaries, and endometrium. This risk relation is probably based on genes which act by increasing the risk for cancer at these sites. Environmental factors that are common among relatives may also play a part. Continued research is required into pathophysiological mechanisms that could explain these observations.
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- Ferrell R. E., Anderson D. E., Chidambaram A., Marino T. R., Badzioch M. A genetic linkage study of familial breast-ovarian cancer. Cancer Genet Cytogenet. 1989 Apr;38(2):241–248. doi: 10.1016/0165-4608(89)90665-1. [DOI] [PubMed] [Google Scholar]
- King M. C., Go R. C., Elston R. C., Lynch H. T., Petrakis N. L. Allele increasing susceptibility to human breast cancer may be linked to the glutamate-pyruvate transaminase locus. Science. 1980 Apr 25;208(4442):406–408. doi: 10.1126/science.7367867. [DOI] [PubMed] [Google Scholar]
- Lynch H. T., Albano W. A., Lynch J. F., Lynch P. M., Campbell A. Surveillance and management of patients at high genetic risk for ovarian carcinoma. Obstet Gynecol. 1982 May;59(5):589–596. [PubMed] [Google Scholar]
- Lynch H. T., Harris R. E., Guirgis H. A., Maloney K., Carmody L. L., Lynch J. F. Familial association of breast/ovarian carcinoma. Cancer. 1978 Apr;41(4):1543–1549. doi: 10.1002/1097-0142(197804)41:4<1543::aid-cncr2820410444>3.0.co;2-y. [DOI] [PubMed] [Google Scholar]
- Narod S. A., Feunteun J., Lynch H. T., Watson P., Conway T., Lynch J., Lenoir G. M. Familial breast-ovarian cancer locus on chromosome 17q12-q23. Lancet. 1991 Jul 13;338(8759):82–83. doi: 10.1016/0140-6736(91)90076-2. [DOI] [PubMed] [Google Scholar]
- Schildkraut J. M., Risch N., Thompson W. D. Evaluating genetic association among ovarian, breast, and endometrial cancer: evidence for a breast/ovarian cancer relationship. Am J Hum Genet. 1989 Oct;45(4):521–529. [PMC free article] [PubMed] [Google Scholar]
- Thiessen E. U. Concerning a familial association between breast cancer and both prostatic and uterine malignancies. Cancer. 1974 Oct;34(4):1102–1107. doi: 10.1002/1097-0142(197410)34:4<1102::aid-cncr2820340421>3.0.co;2-5. [DOI] [PubMed] [Google Scholar]
- Tulinius H., Sigvaldason H., Olafsdóttir G., Tryggvadóttir L. Epidemiology of breast cancer in families in Iceland. J Med Genet. 1992 Mar;29(3):158–164. doi: 10.1136/jmg.29.3.158. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Vatten L. J., Kvinnsland S. Body mass index and risk of breast cancer. A prospective study of 23,826 Norwegian women. Int J Cancer. 1990 Mar 15;45(3):440–444. doi: 10.1002/ijc.2910450311. [DOI] [PubMed] [Google Scholar]
- Williams W. R., Anderson D. E. Genetic epidemiology of breast cancer: segregation analysis of 200 Danish pedigrees. Genet Epidemiol. 1984;1(1):7–20. doi: 10.1002/gepi.1370010104. [DOI] [PubMed] [Google Scholar]