Skip to main content
NCBI home page
Antimicrobial Agents and Chemotherapy logoLink to Antimicrobial Agents and Chemotherapy
. 1994 Dec;38(12):2908–2909. doi: 10.1128/aac.38.12.2908

In vitro activities of 2,2'-bipyridyl analogs against Mycobacterium leprae.

A M Dhople 1, M A Ibanez 1, A A Dhople 1
PMCID: PMC188306  PMID: 7695282

Abstract

In vitro susceptibility of Mycobacterium leprae to two bipyridyl analogs was studied by using two biochemical parameters to measure the metabolic activity of the organism. VUF-8514 at 0.16 micrograms/ml, but not VUF-8842, completely inhibited the metabolic activity of M. leprae, and the action was bactericidal. When compared to rifampin (MIC 0.3 micrograms/ml), VUF-8514 was equally bactericidal against M. leprae.

Full text

PDF
2908

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Baker R. J. The need for new drugs in the treatment and control of leprosy. Int J Lepr Other Mycobact Dis. 1990 Mar;58(1):78–97. [PubMed] [Google Scholar]
  2. Beckers B., Lang H. R., Schimke D., Lammers A. Evaluation of a bioluminescence assay for rapid antimicrobial susceptibility testing of mycobacteria. Eur J Clin Microbiol. 1985 Dec;4(6):556–561. doi: 10.1007/BF02013394. [DOI] [PubMed] [Google Scholar]
  3. Dhople A. M., Green K. J., Osborne L. J. Limited in vitro multiplication of Mycobacterium leprae. Ann Inst Pasteur Microbiol. 1988 Mar-Apr;139(2):213–223. doi: 10.1016/0769-2609(88)90006-3. [DOI] [PubMed] [Google Scholar]
  4. Dhople A. M., Hanks J. H. In vitro growth of Mycobacterium lepraemurium, an obligate intracellular microbe. Science. 1977 Jul 22;197(4301):379–381. doi: 10.1126/science.327548. [DOI] [PubMed] [Google Scholar]
  5. Dhople A. M., Ibanez M. A., Gardner G. D. In vitro synergistic activity between ofloxacin and ansamycins against Mycobacterium leprae. Arzneimittelforschung. 1993 Mar;43(3):384–386. [PubMed] [Google Scholar]
  6. Dhople A. M., Ibanez M. A. In-vitro activity of three new fluoroquinolones and synergy with ansamycins against Mycobacterium leprae. J Antimicrob Chemother. 1993 Sep;32(3):445–451. doi: 10.1093/jac/32.3.445. [DOI] [PubMed] [Google Scholar]
  7. Dhople A. M., Ortega I. An in vitro culture method for screening new drugs against Mycobacterium leprae. Indian J Lepr. 1990 Jan-Mar;62(1):66–75. [PubMed] [Google Scholar]
  8. Dhople A. M., Ortega I., Seydel J. K., Gardner G. D. Effect of brodimoprim on Mycobacterium leprae in vitro and in mouse foot-pads. Indian J Lepr. 1990 Jan-Mar;62(1):76–86. [PubMed] [Google Scholar]
  9. Gelber R. H. Progress in the chemotherapy of leprosy: status, issues and prospects. Prog Drug Res. 1990;34:421–445. doi: 10.1007/978-3-0348-7128-0_14. [DOI] [PubMed] [Google Scholar]
  10. Ji B. H. Drug resistance in leprosy--a review. Lepr Rev. 1985 Dec;56(4):265–278. [PubMed] [Google Scholar]
  11. Ji B., Grosset J. H. Recent advances in the chemotherapy of leprosy. Lepr Rev. 1990 Dec;61(4):313–329. doi: 10.5935/0305-7518.19900029. [DOI] [PubMed] [Google Scholar]
  12. Khanolkar S. R., Ambrose E. J., Chulawala R. G., Bapat C. V. Autoradiographic and metabolic studies of Mycobacterium leprae. Lepr Rev. 1978 Sep;49(3):187–198. [PubMed] [Google Scholar]
  13. Noordeen S. K., Lopez Bravo L., Sundaresan T. K. Estimated number of leprosy cases in the world. Bull World Health Organ. 1992;70(1):7–10. [PMC free article] [PubMed] [Google Scholar]
  14. Seydel J. K., van der Goot H., Timmerman H. Influence of membrane composition of various parasites on the inhibitory activity of a series of bipyridyl analogues. Chemotherapy. 1994 Mar-Apr;40(2):124–135. doi: 10.1159/000239183. [DOI] [PubMed] [Google Scholar]
  15. Timmerman H., Van der Goot H., Seydel J. K. A new series of 2,2'-bipyridyl analogues with high activity against AIDS-complicating micro-organisms. Pharm Weekbl Sci. 1991 Apr 26;13(2):102–103. doi: 10.1007/BF01974989. [DOI] [PubMed] [Google Scholar]
  16. de Zwart M. A., Bastiaans H. M., van der Goot H., Timmerman H. Synthesis and copper-dependent antimycoplasmal activity of amides and amidines derived from 2-amino-1,10-phenanthroline. J Med Chem. 1991 Mar;34(3):1193–1201. doi: 10.1021/jm00107a045. [DOI] [PubMed] [Google Scholar]
  17. de Zwart M. A., van der Goot H., Timmerman H. Synthesis and copper-dependent antimycoplasmal activity of 1-amino-3-(2-pyridyl)isoquinoline derivatives. 1. Amides. J Med Chem. 1988 Apr;31(4):716–722. doi: 10.1021/jm00399a005. [DOI] [PubMed] [Google Scholar]
  18. de Zwart M. A., van der Goot H., Timmerman H. Synthesis and copper-dependent antimycoplasmal activity of 1-amino-3-(2-pyridyl)isoquinoline derivatives. 2. Amidines. J Med Chem. 1989 Feb;32(2):487–493. doi: 10.1021/jm00122a033. [DOI] [PubMed] [Google Scholar]

Articles from Antimicrobial Agents and Chemotherapy are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES