Skip to main content
PMC home page
Antimicrobial Agents and Chemotherapy logoLink to Antimicrobial Agents and Chemotherapy
. 1992 Feb;36(2):277–282. doi: 10.1128/aac.36.2.277

In vitro antibiotic susceptibilities of Neisseria gonorrhoeae isolates in the Philippines.

T E Clendennen 3rd 1, C S Hames 1, E S Kees 1, F C Price 1, W J Rueppel 1, A B Andrada 1, G E Espinosa 1, G Kabrerra 1, F S Wignall 1
PMCID: PMC188352  PMID: 1605592

Abstract

Antibiotic susceptibility surveillance testing was performed on clinical isolates of Neisseria gonorrhoeae collected in September 1989 in the Philippines. beta-Lactamase was produced by 77 (55%) of 140 isolates. In vitro MIC testing revealed significant resistance to penicillin (MIC for 90% of isolates [MIC90], greater than 64 micrograms/ml), tetracycline (MIC90, 4 micrograms/ml), and cefmetazole (MIC90, 8 micrograms/ml). Spectinomycin resistance was rare (10 of 117), but the MIC90 was 32 micrograms/ml. Isolates were susceptible to fluoroquinolones and cephalosporins at the time of this survey, as evidenced by the MIC90s of ciprofloxacin (0.25 microgram/ml), norfloxacin (2.0 micrograms/ml), ofloxacin (0.625 microgram/ml), cefpodoxime (2.0 micrograms/ml), cefotaxime (1.0 microgram/ml), ceftazidime (0.25 microgram/ml), ceftizoxime (0.25 microgram/ml), and ceftriaxone (0.06 microgram/ml). To date, ceftriaxone resistance has not emerged, despite the widespread use of this antibiotic in the Philippines.

Full text

PDF
277

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Berg S. W., Harrison W. O. Spectinomycin as primary treatment of gonorrhea in areas of high prevalence of penicillinase-producing Neisseria gonorrhoeae. Sex Transm Dis. 1981 Jan-Mar;8(1):38–39. [PubMed] [Google Scholar]
  2. Berg S. W., Kilpatrick M. E., Harrison W. O., McCutchan J. A. Cefoxitin as a single-dose treatment for urethritis caused by penicillinase-producing Neisseria gonorrhoeae. N Engl J Med. 1979 Sep 6;301(10):509–511. doi: 10.1056/NEJM197909063011001. [DOI] [PubMed] [Google Scholar]
  3. Crider S. R., Colby S. D., Miller L. K., Harrison W. O., Kerbs S. B., Berg S. W. Treatment of penicillin-resistant Neisseria gonorrhoeae with oral norfloxacin. N Engl J Med. 1984 Jul 19;311(3):137–140. doi: 10.1056/NEJM198407193110301. [DOI] [PubMed] [Google Scholar]
  4. Crider S. R., Kilpatrick M. E., Harrison W. O., Kerbs S. B., Berg S. W. A comparison of penicillin G plus a beta-lactamase inhibitor (sulbactam) with spectinomycin for treatment of urethritis caused by penicillinase-producing Neisseria gonorrhoeae. Sex Transm Dis. 1984 Oct-Dec;11(4):314–317. doi: 10.1097/00007435-198410000-00011. [DOI] [PubMed] [Google Scholar]
  5. Harrison W. O., Hooper R. R., Wiesner P. J., Campbell A. F., Karney W. W., Reynolds G. H., Jones O. G., Holmes K. K. A trial of minocycline given after exposure to prevent gonorrhea. N Engl J Med. 1979 May 10;300(19):1074–1078. doi: 10.1056/NEJM197905103001903. [DOI] [PubMed] [Google Scholar]
  6. Harrison W. O., Wignall F. S., Kerbs S. B., Berg S. W. Oral rosoxacin for treatment of penicillin-resistant gonorrhoea. Lancet. 1984 Mar 10;1(8376):566–566. doi: 10.1016/s0140-6736(84)90962-0. [DOI] [PubMed] [Google Scholar]
  7. Holmes K. K., Johnson D. W., Stewart S., Kvale P. A. Treatment of "penicillin-resistant" gonorrhea in military personnel in S.E. Asia: a cooperative evaluation of tetracycline and of penicillin plus probenecid in 1263 men. Mil Med. 1968 Aug;133(8):642–646. [PubMed] [Google Scholar]
  8. Jones R. N., Gavan T. L., Thornsberry C., Fuchs P. C., Gerlach E. H., Knapp J. S., Murray P., Washington J. A., 2nd Standardization of disk diffusion and agar dilution susceptibility tests for Neisseria gonorrhoeae: interpretive criteria and quality control guidelines for ceftriaxone, penicillin, spectinomycin, and tetracycline. J Clin Microbiol. 1989 Dec;27(12):2758–2766. doi: 10.1128/jcm.27.12.2758-2766.1989. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Jones R. N., Gerlach E. H., Koontz F. P., Murray P. R., Pfaller M. A., Washington J. A., Erwin M. E., Knapp C. C. Interpretive criteria and quality control guidelines for Neisseria gonorrhoeae susceptibility test standardization for cefotetan. J Clin Microbiol. 1991 Feb;29(2):363–366. doi: 10.1128/jcm.29.2.363-366.1991. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Knapp J. S. Laboratory methods for the detection and phenotypic characterization of Neisseria gonorrhoeae strains resistant to antimicrobial agents. Sex Transm Dis. 1988 Oct-Dec;15(4):225–233. doi: 10.1097/00007435-198810000-00009. [DOI] [PubMed] [Google Scholar]
  11. Sanchez P. L., Wignall F. S., Zajdowicz T. R., Kerbs S., Berg S. W., Harrison W. O. One gram of cefoxitin cures uncomplicated gonococcal urethritis caused by penicillinase-producing Neisseria gonorrhoeae (PPNG). Sex Transm Dis. 1983 Jul-Sep;10(3):135–137. doi: 10.1097/00007435-198307000-00007. [DOI] [PubMed] [Google Scholar]
  12. Schwarcz S. K., Zenilman J. M., Schnell D., Knapp J. S., Hook E. W., 3rd, Thompson S., Judson F. N., Holmes K. K. National surveillance of antimicrobial resistance in Neisseria gonorrhoeae. The Gonococcal Isolate Surveillance Project. JAMA. 1990 Sep 19;264(11):1413–1417. [PubMed] [Google Scholar]
  13. Siegel M. S., Thompson S. E., Perine P. L. Penicillinase-producing neisseria gonorrhoeae. Sex Transm Dis. 1977 Jan-Mar;4(1):32–33. [PubMed] [Google Scholar]

Articles from Antimicrobial Agents and Chemotherapy are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES