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. 1992 Oct 17;305(6859):927–931. doi: 10.1136/bmj.305.6859.927

Comparison of Yuzpe regimen, danazol, and mifepristone (RU486) in oral postcoital contraception.

A M Webb 1, J Russell 1, M Elstein 1
PMCID: PMC1883543  PMID: 1458074

Abstract

OBJECTIVE--To compare the effectiveness and acceptability of three regimens of postcoital contraception. DESIGN--Randomised group comparison of ethinyloestradiol 100 micrograms plus levonorgestrel 500 micrograms repeated after 12 hours (Yuzpe method); danazol 600 mg repeated after 12 hours; and mifepristone 600 mg single dose. SETTING--Community family planning clinic. SUBJECTS--616 consecutive women with regular cycles aged 16 to 45 years. MAIN OUTCOME MEASURES--Number of pregnancies, incidence of side effects, and timing of next period. RESULTS--The raw pregnancy rates (with 95% confidence intervals) for the Yuzpe, danazol, and mifepristone groups were 2.62% (0.86% to 6.00%), 4.66% (2.15% to 8.67%), and 0% (0% to 1.87%) respectively. Overall, these rates differed significantly (chi 2 = 8.988, df = 2; p = 0.011). The differences between the mifepristone and Yuzpe groups and between the mifepristone and danazol groups were also significant. Side effects were more common and more severe in the Yuzpe group (133 women (70%)) than in either the danazol group (58 (30%)) or the mifepristone group (72 (37%)). The Yuzpe regimen tended to induce bleeding early but mifepristone prolonged the cycle. Three women bled more than seven days late in the Yuzpe group compared with 49 in the mifepristone group. CONCLUSIONS--Mifepristone was effective in reducing expected pregnancy rates and the Yuzpe method also had a clinical effect. Danazol had little or no effect. A further multicentre trial is needed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Dixon G. W., Schlesselman J. J., Ory H. W., Blye R. P. Ethinyl estradiol and conjugated estrogens as postcoital contraceptives. JAMA. 1980 Sep 19;244(12):1336–1339. [PubMed] [Google Scholar]
  2. Fasoli M., Parazzini F., Cecchetti G., La Vecchia C. Post-coital contraception: an overview of published studies. Contraception. 1989 Apr;39(4):459–468. doi: 10.1016/0010-7824(89)90123-6. [DOI] [PubMed] [Google Scholar]
  3. Haspels A. A. Interception: post-coital estrogens in 3016 women. Contraception. 1976 Oct;14(4):375–381. doi: 10.1016/s0010-7824(76)80052-2. [DOI] [PubMed] [Google Scholar]
  4. Percival-Smith R. K., Abercrombie B. Postcoital contraception with dl-norgestrel/ethinyl estradiol combination: six years experience in a student medical clinic. Contraception. 1987 Sep;36(3):287–293. doi: 10.1016/0010-7824(87)90098-9. [DOI] [PubMed] [Google Scholar]
  5. Rowlands S., Guillebaud J., Bounds W., Booth M. Side effects of danazol compared with an ethinyloestradiol/norgestrel combination when used for postcoital contraception. Contraception. 1983 Jan;27(1):39–49. doi: 10.1016/0010-7824(83)90054-9. [DOI] [PubMed] [Google Scholar]
  6. Schwartz D., Mayaux M. J., Martin-Boyce A., Czyglik F., David G. Donor insemination: conception rate according to cycle day in a series of 821 cycles with a single insemination. Fertil Steril. 1979 Feb;31(2):226–229. doi: 10.1016/s0015-0282(16)43829-x. [DOI] [PubMed] [Google Scholar]
  7. Van Santen M. R., Haspels A. A. A comparison of high-dose estrogens versus low-dose ethinylestradiol and norgestrel combination in postcoital interception: a study in 493 women. Fertil Steril. 1985 Feb;43(2):206–213. doi: 10.1016/s0015-0282(16)48374-3. [DOI] [PubMed] [Google Scholar]
  8. Yuzpe A. A., Smith R. P., Rademaker A. W. A multicenter clinical investigation employing ethinyl estradiol combined with dl-norgestrel as postcoital contraceptive agent. Fertil Steril. 1982 Apr;37(4):508–513. doi: 10.1016/s0015-0282(16)46157-1. [DOI] [PubMed] [Google Scholar]
  9. Zuliani G., Colombo U. F., Molla R. Hormonal postcoital contraception with an ethinylestradiol-norgestrel combination and two danazol regimens. Eur J Obstet Gynecol Reprod Biol. 1990 Dec;37(3):253–260. doi: 10.1016/0028-2243(90)90032-v. [DOI] [PubMed] [Google Scholar]
  10. van Santen M. R., Haspels A. A. Interception. III: Postcoital luteal contragestion by an antiprogestin (mifepristone, RU 486) in 62 women. Contraception. 1987 May;35(5):423–431. doi: 10.1016/0010-7824(87)90078-3. [DOI] [PubMed] [Google Scholar]
  11. van Santen M. R., Haspels A. A. Interception. IV: Failure of mifepristone (RU 486) as a monthly contragestive, "Lunarette". Contraception. 1987 May;35(5):433–438. doi: 10.1016/0010-7824(87)90079-5. [DOI] [PubMed] [Google Scholar]

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