Abstract
Concentrations of oral azoles in serum were compared in a single-dose pharmacologic study in mice. When hydroxypropyl-beta-cyclodextrin was used as a carrier and compared with a standard carrier, polyethylene glycol, drug concentrations determined by bioassay showed that the peak concentration and area under the concentration-time curve were greatly enhanced for itraconazole and saperconazole; moderately enhanced for ketoconazole; but negligibly affected for fluconazole, miconazole, and SCH 42427.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Blum R. A., D'Andrea D. T., Florentino B. M., Wilton J. H., Hilligoss D. M., Gardner M. J., Henry E. B., Goldstein H., Schentag J. J. Increased gastric pH and the bioavailability of fluconazole and ketoconazole. Ann Intern Med. 1991 May 1;114(9):755–757. doi: 10.7326/0003-4819-114-9-755. [DOI] [PubMed] [Google Scholar]
- Brass C., Galgiani J. N., Blaschke T. F., Defelice R., O'Reilly R. A., Stevens D. A. Disposition of ketoconazole, an oral antifungal, in humans. Antimicrob Agents Chemother. 1982 Jan;21(1):151–158. doi: 10.1128/aac.21.1.151. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Denning D. W., Tucker R. M., Hanson L. H., Stevens D. A. Treatment of invasive aspergillosis with itraconazole. Am J Med. 1989 Jun;86(6 Pt 2):791–800. doi: 10.1016/0002-9343(89)90475-0. [DOI] [PubMed] [Google Scholar]
- McEwen J. G., Peters G. R., Blaschke T. F., Brummer E., Perlman A. M., Restrepo A., Stevens D. A. Treatment of paracoccidioidomycosis with itraconazole in a murine model. J Trop Med Hyg. 1985 Oct;88(5):295–299. [PubMed] [Google Scholar]
- Rex J. H., Hanson L. H., Amantea M. A., Stevens D. A., Bennett J. E. Standardization of a fluconazole bioassay and correlation of results with those obtained by high-pressure liquid chromatography. Antimicrob Agents Chemother. 1991 May;35(5):846–850. doi: 10.1128/aac.35.5.846. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Sugar A. M., Alsip S. G., Galgiani J. N., Graybill J. R., Dismukes W. E., Cloud G. A., Craven P. C., Stevens D. A. Pharmacology and toxicity of high-dose ketoconazole. Antimicrob Agents Chemother. 1987 Dec;31(12):1874–1878. doi: 10.1128/aac.31.12.1874. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Uekama K., Otagiri M. Cyclodextrins in drug carrier systems. Crit Rev Ther Drug Carrier Syst. 1987;3(1):1–40. [PubMed] [Google Scholar]
- Wishart J. M. The influence of food on the pharmacokinetics of itraconazole in patients with superficial fungal infection. J Am Acad Dermatol. 1987 Aug;17(2 Pt 1):220–223. doi: 10.1016/s0190-9622(87)70194-7. [DOI] [PubMed] [Google Scholar]