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. 1992 Feb;36(2):489–491. doi: 10.1128/aac.36.2.489

Inhibition of norfloxacin absorption by dairy products.

K T Kivistö 1, P Ojala-Karlsson 1, P J Neuvonen 1
PMCID: PMC188466  PMID: 1605619

Abstract

Seven healthy subjects received, after an overnight fast, a single 200-mg oral dose of norfloxacin with water, whole milk, and unflavored yoghurt. Coadministration of milk or yoghurt reduced the extent of norfloxacin absorption and the mean peak concentration in plasma by approximately 50%. Taking of norfloxacin with these liquid dairy products should be avoided.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Frost R. W., Carlson J. D., Dietz A. J., Jr, Heyd A., Lettieri J. T. Ciprofloxacin pharmacokinetics after a standard or high-fat/high-calcium breakfast. J Clin Pharmacol. 1989 Oct;29(10):953–955. doi: 10.1002/j.1552-4604.1989.tb03260.x. [DOI] [PubMed] [Google Scholar]
  2. Griggs D. J., Wise R. A simple isocratic high-pressure liquid chromatographic assay of quinolones in serum. J Antimicrob Chemother. 1989 Sep;24(3):437–445. doi: 10.1093/jac/24.3.437. [DOI] [PubMed] [Google Scholar]
  3. Holmes B., Brogden R. N., Richards D. M. Norfloxacin. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use. Drugs. 1985 Dec;30(6):482–513. doi: 10.2165/00003495-198530060-00003. [DOI] [PubMed] [Google Scholar]
  4. Hooper D. C., Wolfson J. S. Fluoroquinolone antimicrobial agents. N Engl J Med. 1991 Feb 7;324(6):384–394. doi: 10.1056/NEJM199102073240606. [DOI] [PubMed] [Google Scholar]
  5. Monk J. P., Campoli-Richards D. M. Ofloxacin. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use. Drugs. 1987 Apr;33(4):346–391. doi: 10.2165/00003495-198733040-00003. [DOI] [PubMed] [Google Scholar]
  6. Neuvonen P. J. Interactions with the absorption of tetracyclines. Drugs. 1976;11(1):45–54. doi: 10.2165/00003495-197611010-00004. [DOI] [PubMed] [Google Scholar]
  7. Neuvonen P. J., Kivistö K. T., Lehto P. Interference of dairy products with the absorption of ciprofloxacin. Clin Pharmacol Ther. 1991 Nov;50(5 Pt 1):498–502. doi: 10.1038/clpt.1991.174. [DOI] [PubMed] [Google Scholar]
  8. Neuvonen P. J., Kivistö K. T. The clinical significance of food-drug interactions: a review. Med J Aust. 1989 Jan 2;150(1):36–40. doi: 10.5694/j.1326-5377.1989.tb136321.x. [DOI] [PubMed] [Google Scholar]
  9. Nix D. E., Watson W. A., Lener M. E., Frost R. W., Krol G., Goldstein H., Lettieri J., Schentag J. J. Effects of aluminum and magnesium antacids and ranitidine on the absorption of ciprofloxacin. Clin Pharmacol Ther. 1989 Dec;46(6):700–705. doi: 10.1038/clpt.1989.207. [DOI] [PubMed] [Google Scholar]
  10. Nix D. E., Wilton J. H., Ronald B., Distlerath L., Williams V. C., Norman A. Inhibition of norfloxacin absorption by antacids. Antimicrob Agents Chemother. 1990 Mar;34(3):432–435. doi: 10.1128/aac.34.3.432. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Polk R. E., Healy D. P., Sahai J., Drwal L., Racht E. Effect of ferrous sulfate and multivitamins with zinc on absorption of ciprofloxacin in normal volunteers. Antimicrob Agents Chemother. 1989 Nov;33(11):1841–1844. doi: 10.1128/aac.33.11.1841. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Vance-Bryan K., Guay D. R., Rotschafer J. C. Clinical pharmacokinetics of ciprofloxacin. Clin Pharmacokinet. 1990 Dec;19(6):434–461. doi: 10.2165/00003088-199019060-00003. [DOI] [PubMed] [Google Scholar]
  13. Welling P. G. Interactions affecting drug absorption. Clin Pharmacokinet. 1984 Sep-Oct;9(5):404–434. doi: 10.2165/00003088-198409050-00002. [DOI] [PubMed] [Google Scholar]

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