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. 1992 Feb;36(2):492–494. doi: 10.1128/aac.36.2.492

Inhibitory effects of polyethers on human immunodeficiency virus replication.

M Nakamura 1, S Kunimoto 1, Y Takahashi 1, H Naganawa 1, M Sakaue 1, S Inoue 1, T Ohno 1, T Takeuchi 1
PMCID: PMC188467  PMID: 1605620

Abstract

We examined the inhibitory activities of 10 polyether antibiotics on human immunodeficiency virus (HIV) type 1. These compounds caused concentration-dependent inhibition of HIV replication in primary infected cultures of human T-lymphoblastoid H9 cells. The ratio of 50% effective concentrations for cellular cytotoxicity (MTT assay) to antiviral activity (reverse transcriptase assay) was over 5. Anti-HIV activity was also observed in cultures of monocytic lineage U937 cells chronically infected with HIV.

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Selected References

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