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. 1991 Dec;139(6):1463–1470.

The N terminal region of human tau is present in Alzheimer's disease protein A68 and is incorporated into paired helical filaments.

A Crowe 1, H Ksiezak-Reding 1, W K Liu 1, D W Dickson 1, S H Yen 1
PMCID: PMC1886469  PMID: 1721492

Abstract

Antibody (Ab) E-1 was raised to the amino terminus (19 to 33 amino acid residues) of human tau. It recognized Alzheimer's disease proteins A68 (MW 60, 64, 68 kd), labeled paired helical filaments, and had no reactivity with tau from rat, mouse, and bovine brains. The results indicate that the N terminus of tau is incorporated in A68 proteins and paired helical filaments and that human tau proteins contain species-specific amino acid sequences.

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