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. 1992 May;140(5):1089–1095.

Expression of the bcl-2 gene product in follicular lymphoma.

P Gaulard 1, M F d'Agay 1, M Peuchmaur 1, N Brousse 1, C Gisselbrecht 1, P Solal-Celigny 1, J Diebold 1, D Y Mason 1
PMCID: PMC1886507  PMID: 1374590

Abstract

Expression of bcl-2 protein was analyzed in 140 cases of follicular lymphoma by immunohistologic staining of paraffin-embedded tissue; 85% of cases were positive, the frequency being related to histologic grade (100% for the small-cleaved cell type, 86% for the mixed cell type, and 76% for the large cell group). There was striking heterogeneity of bcl-2 content in a number of cases and the smaller neoplastic cells (i.e., centrocytes) were usually the most strongly labeled. In most cases, bcl-2 protein staining was much weaker in normal lymphoid cells than in the neoplastic cells. In several cases, staining for bcl-2 revealed patterns of neoplastic cell spread into adjacent tissue (e.g., normal follicles, lymphoid sinuses), and bcl-2 protein expression tended to be highest in these migratory cells.

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These references are in PubMed. This may not be the complete list of references from this article.

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