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. 1992 Oct;141(4):767–772.

Amyloidosis in aging and Alzheimer's disease.

D L Price 1, L C Walker 1, L J Martin 1, S S Sisodia 1
PMCID: PMC1886638  PMID: 1415474

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Abraham C. R., Selkoe D. J., Potter H., Price D. L., Cork L. C. Alpha 1-antichymotrypsin is present together with the beta-protein in monkey brain amyloid deposits. Neuroscience. 1989;32(3):715–720. doi: 10.1016/0306-4522(89)90292-3. [DOI] [PubMed] [Google Scholar]
  2. Anderson J. P., Esch F. S., Keim P. S., Sambamurti K., Lieberburg I., Robakis N. K. Exact cleavage site of Alzheimer amyloid precursor in neuronal PC-12 cells. Neurosci Lett. 1991 Jul 8;128(1):126–128. doi: 10.1016/0304-3940(91)90775-o. [DOI] [PubMed] [Google Scholar]
  3. Bachevalier J., Landis L. S., Walker L. C., Brickson M., Mishkin M., Price D. L., Cork L. C. Aged monkeys exhibit behavioral deficits indicative of widespread cerebral dysfunction. Neurobiol Aging. 1991 Mar-Apr;12(2):99–111. doi: 10.1016/0197-4580(91)90048-o. [DOI] [PubMed] [Google Scholar]
  4. Beal M. F., Walker L. C., Storey E., Segar L., Price D. L., Cork L. C. Neurotransmitters in neocortex of aged rhesus monkeys. Neurobiol Aging. 1991 Sep-Oct;12(5):407–412. doi: 10.1016/0197-4580(91)90065-r. [DOI] [PubMed] [Google Scholar]
  5. Braak H., Braak E. Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol. 1991;82(4):239–259. doi: 10.1007/BF00308809. [DOI] [PubMed] [Google Scholar]
  6. Buxbaum J. D., Gandy S. E., Cicchetti P., Ehrlich M. E., Czernik A. J., Fracasso R. P., Ramabhadran T. V., Unterbeck A. J., Greengard P. Processing of Alzheimer beta/A4 amyloid precursor protein: modulation by agents that regulate protein phosphorylation. Proc Natl Acad Sci U S A. 1990 Aug;87(15):6003–6006. doi: 10.1073/pnas.87.15.6003. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Chartier-Harlin M. C., Crawford F., Houlden H., Warren A., Hughes D., Fidani L., Goate A., Rossor M., Roques P., Hardy J. Early-onset Alzheimer's disease caused by mutations at codon 717 of the beta-amyloid precursor protein gene. Nature. 1991 Oct 31;353(6347):844–846. doi: 10.1038/353844a0. [DOI] [PubMed] [Google Scholar]
  8. Cole G. M., Huynh T. V., Saitoh T. Evidence for lysosomal processing of amyloid beta-protein precursor in cultured cells. Neurochem Res. 1989 Oct;14(10):933–939. doi: 10.1007/BF00965926. [DOI] [PubMed] [Google Scholar]
  9. Cork L. C., Masters C., Beyreuther K., Price D. L. Development of senile plaques. Relationships of neuronal abnormalities and amyloid deposits. Am J Pathol. 1990 Dec;137(6):1383–1392. [PMC free article] [PubMed] [Google Scholar]
  10. Cras P., Kawai M., Lowery D., Gonzalez-DeWhitt P., Greenberg B., Perry G. Senile plaque neurites in Alzheimer disease accumulate amyloid precursor protein. Proc Natl Acad Sci U S A. 1991 Sep 1;88(17):7552–7556. doi: 10.1073/pnas.88.17.7552. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Cras P., Kawai M., Siedlak S., Mulvihill P., Gambetti P., Lowery D., Gonzalez-DeWhitt P., Greenberg B., Perry G. Neuronal and microglial involvement in beta-amyloid protein deposition in Alzheimer's disease. Am J Pathol. 1990 Aug;137(2):241–246. [PMC free article] [PubMed] [Google Scholar]
  12. Esch F. S., Keim P. S., Beattie E. C., Blacher R. W., Culwell A. R., Oltersdorf T., McClure D., Ward P. J. Cleavage of amyloid beta peptide during constitutive processing of its precursor. Science. 1990 Jun 1;248(4959):1122–1124. doi: 10.1126/science.2111583. [DOI] [PubMed] [Google Scholar]
  13. Estus S., Golde T. E., Kunishita T., Blades D., Lowery D., Eisen M., Usiak M., Qu X. M., Tabira T., Greenberg B. D. Potentially amyloidogenic, carboxyl-terminal derivatives of the amyloid protein precursor. Science. 1992 Feb 7;255(5045):726–728. doi: 10.1126/science.1738846. [DOI] [PubMed] [Google Scholar]
  14. Evans D. A., Funkenstein H. H., Albert M. S., Scherr P. A., Cook N. R., Chown M. J., Hebert L. E., Hennekens C. H., Taylor J. O. Prevalence of Alzheimer's disease in a community population of older persons. Higher than previously reported. JAMA. 1989 Nov 10;262(18):2551–2556. [PubMed] [Google Scholar]
  15. Frautschy S. A., Baird A., Cole G. M. Effects of injected Alzheimer beta-amyloid cores in rat brain. Proc Natl Acad Sci U S A. 1991 Oct 1;88(19):8362–8366. doi: 10.1073/pnas.88.19.8362. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Gandy S., Czernik A. J., Greengard P. Phosphorylation of Alzheimer disease amyloid precursor peptide by protein kinase C and Ca2+/calmodulin-dependent protein kinase II. Proc Natl Acad Sci U S A. 1988 Aug;85(16):6218–6221. doi: 10.1073/pnas.85.16.6218. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Glenner G. G., Wong C. W. Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. Biochem Biophys Res Commun. 1984 May 16;120(3):885–890. doi: 10.1016/s0006-291x(84)80190-4. [DOI] [PubMed] [Google Scholar]
  18. Goate A., Chartier-Harlin M. C., Mullan M., Brown J., Crawford F., Fidani L., Giuffra L., Haynes A., Irving N., James L. Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease. Nature. 1991 Feb 21;349(6311):704–706. doi: 10.1038/349704a0. [DOI] [PubMed] [Google Scholar]
  19. Golde T. E., Estus S., Usiak M., Younkin L. H., Younkin S. G. Expression of beta amyloid protein precursor mRNAs: recognition of a novel alternatively spliced form and quantitation in Alzheimer's disease using PCR. Neuron. 1990 Feb;4(2):253–267. doi: 10.1016/0896-6273(90)90100-t. [DOI] [PubMed] [Google Scholar]
  20. Haass C., Koo E. H., Mellon A., Hung A. Y., Selkoe D. J. Targeting of cell-surface beta-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments. Nature. 1992 Jun 11;357(6378):500–503. doi: 10.1038/357500a0. [DOI] [PubMed] [Google Scholar]
  21. Hyman B. T., Van Hoesen G. W., Damasio A. R. Memory-related neural systems in Alzheimer's disease: an anatomic study. Neurology. 1990 Nov;40(11):1721–1730. doi: 10.1212/wnl.40.11.1721. [DOI] [PubMed] [Google Scholar]
  22. Johnson S. A., McNeill T., Cordell B., Finch C. E. Relation of neuronal APP-751/APP-695 mRNA ratio and neuritic plaque density in Alzheimer's disease. Science. 1990 May 18;248(4957):854–857. doi: 10.1126/science.2111579. [DOI] [PubMed] [Google Scholar]
  23. Jucker M., Walker L. C., Martin L. J., Kitt C. A., Kleinman H. K., Ingram D. K., Price D. L. Age-associated inclusions in normal and transgenic mouse brain. Science. 1992 Mar 13;255(5050):1443–1445. doi: 10.1126/science.1542796. [DOI] [PubMed] [Google Scholar]
  24. Kang J., Lemaire H. G., Unterbeck A., Salbaum J. M., Masters C. L., Grzeschik K. H., Multhaup G., Beyreuther K., Müller-Hill B. The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor. Nature. 1987 Feb 19;325(6106):733–736. doi: 10.1038/325733a0. [DOI] [PubMed] [Google Scholar]
  25. Kawabata S., Higgins G. A., Gordon J. W. Amyloid plaques, neurofibrillary tangles and neuronal loss in brains of transgenic mice overexpressing a C-terminal fragment of human amyloid precursor protein. Nature. 1991 Dec 12;354(6353):476–478. doi: 10.1038/354476a0. [DOI] [PubMed] [Google Scholar]
  26. Kawai M., Cras P., Richey P., Tabaton M., Lowery D. E., Gonzalez-DeWhitt P. A., Greenberg B. D., Gambetti P., Perry G. Subcellular localization of amyloid precursor protein in senile plaques of Alzheimer's disease. Am J Pathol. 1992 Apr;140(4):947–958. [PMC free article] [PubMed] [Google Scholar]
  27. Kitaguchi N., Takahashi Y., Tokushima Y., Shiojiri S., Ito H. Novel precursor of Alzheimer's disease amyloid protein shows protease inhibitory activity. Nature. 1988 Feb 11;331(6156):530–532. doi: 10.1038/331530a0. [DOI] [PubMed] [Google Scholar]
  28. Kitt C. A., Price D. L., Struble R. G., Cork L. C., Wainer B. H., Becher M. W., Mobley W. C. Evidence for cholinergic neurites in senile plaques. Science. 1984 Dec 21;226(4681):1443–1445. doi: 10.1126/science.6505701. [DOI] [PubMed] [Google Scholar]
  29. Kitt C. A., Struble R. G., Cork L. C., Mobley W. C., Walker L. C., Joh T. H., Price D. L. Catecholaminergic neurites in senile plaques in prefrontal cortex of aged nonhuman primates. Neuroscience. 1985 Nov;16(3):691–699. doi: 10.1016/0306-4522(85)90202-7. [DOI] [PubMed] [Google Scholar]
  30. Koo E. H., Sisodia S. S., Archer D. R., Martin L. J., Weidemann A., Beyreuther K., Fischer P., Masters C. L., Price D. L. Precursor of amyloid protein in Alzheimer disease undergoes fast anterograde axonal transport. Proc Natl Acad Sci U S A. 1990 Feb;87(4):1561–1565. doi: 10.1073/pnas.87.4.1561. [DOI] [PMC free article] [PubMed] [Google Scholar]
  31. Koo E. H., Sisodia S. S., Cork L. C., Unterbeck A., Bayney R. M., Price D. L. Differential expression of amyloid precursor protein mRNAs in cases of Alzheimer's disease and in aged nonhuman primates. Neuron. 1990 Jan;4(1):97–104. doi: 10.1016/0896-6273(90)90446-m. [DOI] [PubMed] [Google Scholar]
  32. Kowall N. W., Beal M. F., Busciglio J., Duffy L. K., Yankner B. A. An in vivo model for the neurodegenerative effects of beta amyloid and protection by substance P. Proc Natl Acad Sci U S A. 1991 Aug 15;88(16):7247–7251. doi: 10.1073/pnas.88.16.7247. [DOI] [PMC free article] [PubMed] [Google Scholar]
  33. König G., Salbaum J. M., Wiestler O., Lang W., Schmitt H. P., Masters C. L., Beyreuther K. Alternative splicing of the beta A4 amyloid gene of Alzheimer's disease in cortex of control and Alzheimer's disease patients. Brain Res Mol Brain Res. 1991 Feb;9(3):259–262. doi: 10.1016/0169-328x(91)90010-u. [DOI] [PubMed] [Google Scholar]
  34. Levy E., Carman M. D., Fernandez-Madrid I. J., Power M. D., Lieberburg I., van Duinen S. G., Bots G. T., Luyendijk W., Frangione B. Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage, Dutch type. Science. 1990 Jun 1;248(4959):1124–1126. doi: 10.1126/science.2111584. [DOI] [PubMed] [Google Scholar]
  35. Mann D. M., Esiri M. M. The pattern of acquisition of plaques and tangles in the brains of patients under 50 years of age with Down's syndrome. J Neurol Sci. 1989 Feb;89(2-3):169–179. doi: 10.1016/0022-510x(89)90019-1. [DOI] [PubMed] [Google Scholar]
  36. Martin L. J., Sisodia S. S., Koo E. H., Cork L. C., Dellovade T. L., Weidemann A., Beyreuther K., Masters C., Price D. L. Amyloid precursor protein in aged nonhuman primates. Proc Natl Acad Sci U S A. 1991 Feb 15;88(4):1461–1465. doi: 10.1073/pnas.88.4.1461. [DOI] [PMC free article] [PubMed] [Google Scholar]
  37. Masliah E., Hansen L., Albright T., Mallory M., Terry R. D. Immunoelectron microscopic study of synaptic pathology in Alzheimer's disease. Acta Neuropathol. 1991;81(4):428–433. doi: 10.1007/BF00293464. [DOI] [PubMed] [Google Scholar]
  38. Masliah E., Terry R. D., DeTeresa R. M., Hansen L. A. Immunohistochemical quantification of the synapse-related protein synaptophysin in Alzheimer disease. Neurosci Lett. 1989 Aug 28;103(2):234–239. doi: 10.1016/0304-3940(89)90582-x. [DOI] [PubMed] [Google Scholar]
  39. Masters C. L., Multhaup G., Simms G., Pottgiesser J., Martins R. N., Beyreuther K. Neuronal origin of a cerebral amyloid: neurofibrillary tangles of Alzheimer's disease contain the same protein as the amyloid of plaque cores and blood vessels. EMBO J. 1985 Nov;4(11):2757–2763. doi: 10.1002/j.1460-2075.1985.tb04000.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  40. Masters C. L., Simms G., Weinman N. A., Multhaup G., McDonald B. L., Beyreuther K. Amyloid plaque core protein in Alzheimer disease and Down syndrome. Proc Natl Acad Sci U S A. 1985 Jun;82(12):4245–4249. doi: 10.1073/pnas.82.12.4245. [DOI] [PMC free article] [PubMed] [Google Scholar]
  41. McKhann G., Drachman D., Folstein M., Katzman R., Price D., Stadlan E. M. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology. 1984 Jul;34(7):939–944. doi: 10.1212/wnl.34.7.939. [DOI] [PubMed] [Google Scholar]
  42. Murrell J., Farlow M., Ghetti B., Benson M. D. A mutation in the amyloid precursor protein associated with hereditary Alzheimer's disease. Science. 1991 Oct 4;254(5028):97–99. doi: 10.1126/science.1925564. [DOI] [PubMed] [Google Scholar]
  43. Naruse S., Igarashi S., Kobayashi H., Aoki K., Inuzuka T., Kaneko K., Shimizu T., Iihara K., Kojima T., Miyatake T. Mis-sense mutation Val----Ile in exon 17 of amyloid precursor protein gene in Japanese familial Alzheimer's disease. Lancet. 1991 Apr 20;337(8747):978–979. doi: 10.1016/0140-6736(91)91612-x. [DOI] [PubMed] [Google Scholar]
  44. Oltersdorf T., Fritz L. C., Schenk D. B., Lieberburg I., Johnson-Wood K. L., Beattie E. C., Ward P. J., Blacher R. W., Dovey H. F., Sinha S. The secreted form of the Alzheimer's amyloid precursor protein with the Kunitz domain is protease nexin-II. Nature. 1989 Sep 14;341(6238):144–147. doi: 10.1038/341144a0. [DOI] [PubMed] [Google Scholar]
  45. Palmert M. R., Podlisny M. B., Witker D. S., Oltersdorf T., Younkin L. H., Selkoe D. J., Younkin S. G. The beta-amyloid protein precursor of Alzheimer disease has soluble derivatives found in human brain and cerebrospinal fluid. Proc Natl Acad Sci U S A. 1989 Aug;86(16):6338–6342. doi: 10.1073/pnas.86.16.6338. [DOI] [PMC free article] [PubMed] [Google Scholar]
  46. Pike C. J., Walencewicz A. J., Glabe C. G., Cotman C. W. Aggregation-related toxicity of synthetic beta-amyloid protein in hippocampal cultures. Eur J Pharmacol. 1991 Aug 14;207(4):367–368. doi: 10.1016/0922-4106(91)90014-9. [DOI] [PubMed] [Google Scholar]
  47. Ponte P., Gonzalez-DeWhitt P., Schilling J., Miller J., Hsu D., Greenberg B., Davis K., Wallace W., Lieberburg I., Fuller F. A new A4 amyloid mRNA contains a domain homologous to serine proteinase inhibitors. Nature. 1988 Feb 11;331(6156):525–527. doi: 10.1038/331525a0. [DOI] [PubMed] [Google Scholar]
  48. Prelli F., Castaño E., Glenner G. G., Frangione B. Differences between vascular and plaque core amyloid in Alzheimer's disease. J Neurochem. 1988 Aug;51(2):648–651. doi: 10.1111/j.1471-4159.1988.tb01087.x. [DOI] [PubMed] [Google Scholar]
  49. Probst A., Langui D., Ipsen S., Robakis N., Ulrich J. Deposition of beta/A4 protein along neuronal plasma membranes in diffuse senile plaques. Acta Neuropathol. 1991;83(1):21–29. doi: 10.1007/BF00294426. [DOI] [PubMed] [Google Scholar]
  50. Quon D., Wang Y., Catalano R., Scardina J. M., Murakami K., Cordell B. Formation of beta-amyloid protein deposits in brains of transgenic mice. Nature. 1991 Jul 18;352(6332):239–241. doi: 10.1038/352239a0. [DOI] [PubMed] [Google Scholar]
  51. Selkoe D. J., Bell D. S., Podlisny M. B., Price D. L., Cork L. C. Conservation of brain amyloid proteins in aged mammals and humans with Alzheimer's disease. Science. 1987 Feb 20;235(4791):873–877. doi: 10.1126/science.3544219. [DOI] [PubMed] [Google Scholar]
  52. Sisodia S. S. Beta-amyloid precursor protein cleavage by a membrane-bound protease. Proc Natl Acad Sci U S A. 1992 Jul 1;89(13):6075–6079. doi: 10.1073/pnas.89.13.6075. [DOI] [PMC free article] [PubMed] [Google Scholar]
  53. Sisodia S. S., Koo E. H., Beyreuther K., Unterbeck A., Price D. L. Evidence that beta-amyloid protein in Alzheimer's disease is not derived by normal processing. Science. 1990 Apr 27;248(4954):492–495. doi: 10.1126/science.1691865. [DOI] [PubMed] [Google Scholar]
  54. Struble R. G., Cork L. C., Whitehouse P. J., Price D. L. Cholinergic innervation in neuritic plaques. Science. 1982 Apr 23;216(4544):413–415. doi: 10.1126/science.6803359. [DOI] [PubMed] [Google Scholar]
  55. Struble R. G., Price D. L., Jr, Cork L. C., Price D. L. Senile plaques in cortex of aged normal monkeys. Brain Res. 1985 Dec 30;361(1-2):267–275. doi: 10.1016/0006-8993(85)91298-3. [DOI] [PubMed] [Google Scholar]
  56. Tagliavini F., Ghiso J., Timmers W. F., Giaccone G., Bugiani O., Frangione B. Coexistence of Alzheimer's amyloid precursor protein and amyloid protein in cerebral vessel walls. Lab Invest. 1990 Jun;62(6):761–767. [PubMed] [Google Scholar]
  57. Terry R. D., Masliah E., Salmon D. P., Butters N., DeTeresa R., Hill R., Hansen L. A., Katzman R. Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment. Ann Neurol. 1991 Oct;30(4):572–580. doi: 10.1002/ana.410300410. [DOI] [PubMed] [Google Scholar]
  58. Van Broeckhoven C., Haan J., Bakker E., Hardy J. A., Van Hul W., Wehnert A., Vegter-Van der Vlis M., Roos R. A. Amyloid beta protein precursor gene and hereditary cerebral hemorrhage with amyloidosis (Dutch). Science. 1990 Jun 1;248(4959):1120–1122. doi: 10.1126/science.1971458. [DOI] [PubMed] [Google Scholar]
  59. Walker L. C., Kitt C. A., Cork L. C., Struble R. G., Dellovade T. L., Price D. L. Multiple transmitter systems contribute neurites to individual senile plaques. J Neuropathol Exp Neurol. 1988 Mar;47(2):138–144. doi: 10.1097/00005072-198803000-00006. [DOI] [PMC free article] [PubMed] [Google Scholar]
  60. Walker L. C., Masters C., Beyreuther K., Price D. L. Amyloid in the brains of aged squirrel monkeys. Acta Neuropathol. 1990;80(4):381–387. doi: 10.1007/BF00307691. [DOI] [PubMed] [Google Scholar]
  61. Wang R., Meschia J. F., Cotter R. J., Sisodia S. S. Secretion of the beta/A4 amyloid precursor protein. Identification of a cleavage site in cultured mammalian cells. J Biol Chem. 1991 Sep 5;266(25):16960–16964. [PubMed] [Google Scholar]
  62. Weidemann A., König G., Bunke D., Fischer P., Salbaum J. M., Masters C. L., Beyreuther K. Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein. Cell. 1989 Apr 7;57(1):115–126. doi: 10.1016/0092-8674(89)90177-3. [DOI] [PubMed] [Google Scholar]
  63. Wenk G. L., Walker L. C., Price D. L., Cork L. C. Loss of NMDA, but not GABA-A, binding in the brains of aged rats and monkeys. Neurobiol Aging. 1991 Mar-Apr;12(2):93–98. doi: 10.1016/0197-4580(91)90047-n. [DOI] [PubMed] [Google Scholar]
  64. Yankner B. A., Caceres A., Duffy L. K. Nerve growth factor potentiates the neurotoxicity of beta amyloid. Proc Natl Acad Sci U S A. 1990 Nov;87(22):9020–9023. doi: 10.1073/pnas.87.22.9020. [DOI] [PMC free article] [PubMed] [Google Scholar]
  65. Yankner B. A., Duffy L. K., Kirschner D. A. Neurotrophic and neurotoxic effects of amyloid beta protein: reversal by tachykinin neuropeptides. Science. 1990 Oct 12;250(4978):279–282. doi: 10.1126/science.2218531. [DOI] [PubMed] [Google Scholar]

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