Skip to main content
PMC home page
The American Journal of Pathology logoLink to The American Journal of Pathology
. 1993 Jan;142(1):285–292.

Immunoglobulin specificity of low grade B cell gastrointestinal lymphoma of mucosa-associated lymphoid tissue (MALT) type.

T Hussell 1, P G Isaacson 1, J E Crabtree 1, A Dogan 1, J Spencer 1
PMCID: PMC1886827  PMID: 8424461

Abstract

The specificity of the tumor cell immunoglobulin in three cases of low grade B cell gastrointestinal mucosa-associated lymphoid tissue (MALT) lymphoma has been studied. Using anti-idiotypic antibodies to detect the reactivity of tumor immunoglobulin in tissue sections from the patients and other individuals, we observed specificity for normal tissue components in all three cases studied. Reactivity in one case was with follicular dendritic cells, in the second case with a novel antigen on mucosal post capillary venules, and, in the third case, a broad pattern of reactivity was observed. This study suggests that autoimmunity may play a role in the pathogenesis of gastric lymphoma.

Full text

PDF
285

Images in this article

289Figure 2
on p.289
290Figure 3
on p.290
291Figure 4
on p.291

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bröker B. M., Klajman A., Youinou P., Jouquan J., Worman C. P., Murphy J., Mackenzie L., Quartey-Papafio R., Blaschek M., Collins P. Chronic lymphocytic leukemic (CLL) cells secrete multispecific autoantibodies. J Autoimmun. 1988 Oct;1(5):469–481. doi: 10.1016/0896-8411(88)90068-6. [DOI] [PubMed] [Google Scholar]
  2. Casali P., Notkins A. L. Probing the human B-cell repertoire with EBV: polyreactive antibodies and CD5+ B lymphocytes. Annu Rev Immunol. 1989;7:513–535. doi: 10.1146/annurev.iy.07.040189.002501. [DOI] [PubMed] [Google Scholar]
  3. Chan J. K., Ng C. S., Isaacson P. G. Relationship between high-grade lymphoma and low-grade B-cell mucosa-associated lymphoid tissue lymphoma (MALToma) of the stomach. Am J Pathol. 1990 May;136(5):1153–1164. [PMC free article] [PubMed] [Google Scholar]
  4. Crago S. S., Kulhavy R., Prince S. J., Mestecky J. Secretory component of epithelial cells is a surface receptor for polymeric immunoglobulins. J Exp Med. 1978 Jun 1;147(6):1832–1837. doi: 10.1084/jem.147.6.1832. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Dighiero G., Hart S., Lim A., Borche L., Levy R., Miller R. A. Autoantibody activity of immunoglobulins isolated from B-cell follicular lymphomas. Blood. 1991 Aug 1;78(3):581–585. [PubMed] [Google Scholar]
  6. Hyjek E., Isaacson P. G. Primary B cell lymphoma of the thyroid and its relationship to Hashimoto's thyroiditis. Hum Pathol. 1988 Nov;19(11):1315–1326. doi: 10.1016/s0046-8177(88)80287-9. [DOI] [PubMed] [Google Scholar]
  7. Hyjek E., Smith W. J., Isaacson P. G. Primary B-cell lymphoma of salivary glands and its relationship to myoepithelial sialadenitis. Hum Pathol. 1988 Jul;19(7):766–776. doi: 10.1016/s0046-8177(88)80259-4. [DOI] [PubMed] [Google Scholar]
  8. Isaacson P. G., Spencer J., Finn T. Primary B-cell gastric lymphoma. Hum Pathol. 1986 Jan;17(1):72–82. doi: 10.1016/s0046-8177(86)80157-5. [DOI] [PubMed] [Google Scholar]
  9. Isaacson P. G., Spencer J. Malignant lymphoma of mucosa-associated lymphoid tissue. Histopathology. 1987 May;11(5):445–462. doi: 10.1111/j.1365-2559.1987.tb02654.x. [DOI] [PubMed] [Google Scholar]
  10. Kosco M. H., Gray D. Signals involved in germinal center reactions. Immunol Rev. 1992 Apr;126:63–76. doi: 10.1111/j.1600-065x.1992.tb00631.x. [DOI] [PubMed] [Google Scholar]
  11. Schriever F., Freedman A. S., Freeman G., Messner E., Lee G., Daley J., Nadler L. M. Isolated human follicular dendritic cells display a unique antigenic phenotype. J Exp Med. 1989 Jun 1;169(6):2043–2058. doi: 10.1084/jem.169.6.2043. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Spencer J., Diss T. C., Isaacson P. G. A study of the properties of a low-grade mucosal B-cell lymphoma using a monoclonal antibody specific for the tumour immunoglobulin. J Pathol. 1990 Mar;160(3):231–238. doi: 10.1002/path.1711600309. [DOI] [PubMed] [Google Scholar]
  13. Spencer J., Finn T., Isaacson P. G. Human Peyer's patches: an immunohistochemical study. Gut. 1986 Apr;27(4):405–410. doi: 10.1136/gut.27.4.405. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Sthoeger Z. M., Wakai M., Tse D. B., Vinciguerra V. P., Allen S. L., Budman D. R., Lichtman S. M., Schulman P., Weiselberg L. R., Chiorazzi N. Production of autoantibodies by CD5-expressing B lymphocytes from patients with chronic lymphocytic leukemia. J Exp Med. 1989 Jan 1;169(1):255–268. doi: 10.1084/jem.169.1.255. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Tew J. G., Kosco M. H., Burton G. F., Szakal A. K. Follicular dendritic cells as accessory cells. Immunol Rev. 1990 Oct;117:185–211. doi: 10.1111/j.1600-065x.1990.tb00573.x. [DOI] [PubMed] [Google Scholar]
  16. Tew J. G., Phipps R. P., Mandel T. E. The maintenance and regulation of the humoral immune response: persisting antigen and the role of follicular antigen-binding dendritic cells as accessory cells. Immunol Rev. 1980;53:175–201. doi: 10.1111/j.1600-065x.1980.tb01044.x. [DOI] [PubMed] [Google Scholar]
  17. Wotherspoon A. C., Ortiz-Hidalgo C., Falzon M. R., Isaacson P. G. Helicobacter pylori-associated gastritis and primary B-cell gastric lymphoma. Lancet. 1991 Nov 9;338(8776):1175–1176. doi: 10.1016/0140-6736(91)92035-z. [DOI] [PubMed] [Google Scholar]

Articles from The American Journal of Pathology are provided here courtesy of American Society for Investigative Pathology

RESOURCES