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. 1995 Feb;69(2):1306–1309. doi: 10.1128/jvi.69.2.1306-1309.1995

Induction of protective cytotoxic T cells to murine cytomegalovirus by using a nonapeptide and a human-compatible adjuvant (Montanide ISA 720).

A A Scalzo 1, S L Elliott 1, J Cox 1, J Gardner 1, D J Moss 1, A Suhrbier 1
PMCID: PMC188710  PMID: 7815511

Abstract

The use of synthetic peptides representing cytotoxic T-cell (CTL) epitopes for human vaccination requires the identification of a suitable adjuvant formulation. A single immunization with Montanide ISA720/tetanus toxoid/YPHFMPTNL protected mice against murine cytomegalovirus and induced epitope-specific CTL. Such formulations will find application in peptide-based CTL anti-viral vaccines.

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Selected References

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