Skip to main content
NCBI home page
The American Journal of Pathology logoLink to The American Journal of Pathology
. 1994 Feb;144(2):209–214.

Role of human immunodeficiency virus infection in the pathogenesis of human papillomavirus-associated cervical neoplasia.

L Braun 1
PMCID: PMC1887153  PMID: 8311108

Abstract

Although many basic questions about the relationship between HIV and HPV infection remain unresolved, epidemiological studies have consistently shown a strong association between HIV infection and the development of HPV-related squamous intraepithelial neoplasia. This work indicates that HIV infection may promote the clinical manifestation of subclinical or latent HPV infection. Recent technical advances localizing virus DNA and gene products in situ will provide new avenues for investigation, allowing us to go beyond correlations and to clarify the mechanisms of interaction between the two viruses in individual patients. With improved antiretroviral therapy and prophylaxis for HIV-associated opportunistic infection and prolonged survival of women with HIV, HPV infection and its most serious consequence, cervical cancer, are likely to assume greater significance in the clinical management of HIV-infected women throughout the world. A better understanding of the role of HIV in promoting the clinical manifestation of HPV infection will be essential to the control of this disease.

Full text

PDF
209

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Adachi A., Fleming I., Burk R. D., Ho G. Y., Klein R. S. Women with human immunodeficiency virus infection and abnormal Papanicolaou smears: a prospective study of colposcopy and clinical outcome. Obstet Gynecol. 1993 Mar;81(3):372–377. [PubMed] [Google Scholar]
  2. Braun L., Dürst M., Mikumo R., Crowley A., Robinson M. Regulation of growth and gene expression in human papillomavirus-transformed keratinocytes by transforming growth factor-beta: implications for the control of papillomavirus infection. Mol Carcinog. 1992;6(2):100–111. doi: 10.1002/mc.2940060205. [DOI] [PubMed] [Google Scholar]
  3. Braun L., Dürst M., Mikumo R., Gruppuso P. Differential response of nontumorigenic and tumorigenic human papillomavirus type 16-positive epithelial cells to transforming growth factor beta 1. Cancer Res. 1990 Nov 15;50(22):7324–7332. [PubMed] [Google Scholar]
  4. Brichacek B., Derderian C., Chermann J. C., Hirsch I. HIV-1 infectivity of human carcinoma cell lines lacking CD4 receptors. Cancer Lett. 1992 Mar 31;63(1):23–31. doi: 10.1016/0304-3835(92)90085-a. [DOI] [PubMed] [Google Scholar]
  5. Carpenter C. C., Mayer K. H., Stein M. D., Leibman B. D., Fisher A., Fiore T. C. Human immunodeficiency virus infection in North American women: experience with 200 cases and a review of the literature. Medicine (Baltimore) 1991 Sep;70(5):307–325. doi: 10.1097/00005792-199109000-00003. [DOI] [PubMed] [Google Scholar]
  6. Carson L. F., Twiggs L. B., Fukushima M., Ostrow R. S., Faras A. J., Okagaki T. Human genital papilloma infections: an evaluation of immunologic competence in the genital neoplasia-papilloma syndrome. Am J Obstet Gynecol. 1986 Oct;155(4):784–789. doi: 10.1016/s0002-9378(86)80021-7. [DOI] [PubMed] [Google Scholar]
  7. Desaintes C., Hallez S., Van Alphen P., Burny A. Transcriptional activation of several heterologous promoters by the E6 protein of human papillomavirus type 16. J Virol. 1992 Jan;66(1):325–333. doi: 10.1128/jvi.66.1.325-333.1992. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Feingold A. R., Vermund S. H., Burk R. D., Kelley K. F., Schrager L. K., Schreiber K., Munk G., Friedland G. H., Klein R. S. Cervical cytologic abnormalities and papillomavirus in women infected with human immunodeficiency virus. J Acquir Immune Defic Syndr. 1990;3(9):896–903. [PubMed] [Google Scholar]
  9. Halpert R., Fruchter R. G., Sedlis A., Butt K., Boyce J. G., Sillman F. H. Human papillomavirus and lower genital neoplasia in renal transplant patients. Obstet Gynecol. 1986 Aug;68(2):251–258. [PubMed] [Google Scholar]
  10. Hashida T., Yasumoto S. Induction of chromosome abnormalities in mouse and human epidermal keratinocytes by the human papillomavirus type 16 E7 oncogene. J Gen Virol. 1991 Jul;72(Pt 7):1569–1577. doi: 10.1099/0022-1317-72-7-1569. [DOI] [PubMed] [Google Scholar]
  11. Henry M. J., Stanley M. W., Cruikshank S., Carson L. Association of human immunodeficiency virus-induced immunosuppression with human papillomavirus infection and cervical intraepithelial neoplasia. Am J Obstet Gynecol. 1989 Feb;160(2):352–353. doi: 10.1016/0002-9378(89)90441-9. [DOI] [PubMed] [Google Scholar]
  12. Jackson M. E., Campo M. S., Gaukroger J. M. Cooperation between papillomavirus and chemical cofactors in oncogenesis. Crit Rev Oncog. 1993;4(3):277–291. [PubMed] [Google Scholar]
  13. Johnson J. C., Burnett A. F., Willet G. D., Young M. A., Doniger J. High frequency of latent and clinical human papillomavirus cervical infections in immunocompromised human immunodeficiency virus-infected women. Obstet Gynecol. 1992 Mar;79(3):321–327. doi: 10.1097/00006250-199203000-00001. [DOI] [PubMed] [Google Scholar]
  14. Judson F. N. Interactions between human papillomavirus and human immunodeficiency virus infections. IARC Sci Publ. 1992;(119):199–207. [PubMed] [Google Scholar]
  15. Kanagawa O., Vaupel B. A., Gayama S., Koehler G., Kopf M. Resistance of mice deficient in IL-4 to retrovirus-induced immunodeficiency syndrome (MAIDS) Science. 1993 Oct 8;262(5131):240–242. doi: 10.1126/science.8211142. [DOI] [PubMed] [Google Scholar]
  16. Maiman M., Fruchter R. G., Serur E., Remy J. C., Feuer G., Boyce J. Human immunodeficiency virus infection and cervical neoplasia. Gynecol Oncol. 1990 Sep;38(3):377–382. doi: 10.1016/0090-8258(90)90077-x. [DOI] [PubMed] [Google Scholar]
  17. Matorras R., Ariceta J. M., Rementeria A., Corral J., Gutierrez de Terán G., Diez J., Montoya F., Rodriguez-Escudero F. J. Human immunodeficiency virus-induced immunosuppression: a risk factor for human papillomavirus infection. Am J Obstet Gynecol. 1991 Jan;164(1 Pt 1):42–44. doi: 10.1016/0002-9378(91)90620-7. [DOI] [PubMed] [Google Scholar]
  18. Mosca J. D., Bednarik D. P., Raj N. B., Rosen C. A., Sodroski J. G., Haseltine W. A., Pitha P. M. Herpes simplex virus type-1 can reactivate transcription of latent human immunodeficiency virus. Nature. 1987 Jan 1;325(6099):67–70. doi: 10.1038/325067a0. [DOI] [PubMed] [Google Scholar]
  19. Nuovo G. J., Forde A., MacConnell P., Fahrenwald R. In situ detection of PCR-amplified HIV-1 nucleic acids and tumor necrosis factor cDNA in cervical tissues. Am J Pathol. 1993 Jul;143(1):40–48. [PMC free article] [PubMed] [Google Scholar]
  20. Nuovo G. J., MacConnell P., Forde A., Delvenne P. Detection of human papillomavirus DNA in formalin-fixed tissues by in situ hybridization after amplification by polymerase chain reaction. Am J Pathol. 1991 Oct;139(4):847–854. [PMC free article] [PubMed] [Google Scholar]
  21. Penn I. Cancers of the anogenital region in renal transplant recipients. Analysis of 65 cases. Cancer. 1986 Aug 1;58(3):611–616. doi: 10.1002/1097-0142(19860801)58:3<611::aid-cncr2820580303>3.0.co;2-m. [DOI] [PubMed] [Google Scholar]
  22. Poli G., Kinter A. L., Justement J. S., Bressler P., Kehrl J. H., Fauci A. S. Transforming growth factor beta suppresses human immunodeficiency virus expression and replication in infected cells of the monocyte/macrophage lineage. J Exp Med. 1991 Mar 1;173(3):589–597. doi: 10.1084/jem.173.3.589. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Provencher D., Valme B., Averette H. E., Ganjei P., Donato D., Penalver M., Sevin B. U. HIV status and positive Papanicolaou screening: identification of a high-risk population. Gynecol Oncol. 1988 Sep;31(1):184–190. doi: 10.1016/0090-8258(88)90291-0. [DOI] [PubMed] [Google Scholar]
  24. Schäfer A., Friedmann W., Mielke M., Schwartländer B., Koch M. A. The increased frequency of cervical dysplasia-neoplasia in women infected with the human immunodeficiency virus is related to the degree of immunosuppression. Am J Obstet Gynecol. 1991 Feb;164(2):593–599. doi: 10.1016/s0002-9378(11)80029-3. [DOI] [PubMed] [Google Scholar]
  25. Spinillo A., Tenti P., Zappatore R., De Seta F., Silini E., Guaschino S. Langerhans' cell counts and cervical intraepithelial neoplasia in women with human immunodeficiency virus infection. Gynecol Oncol. 1993 Feb;48(2):210–213. doi: 10.1006/gyno.1993.1035. [DOI] [PubMed] [Google Scholar]
  26. Van de Perre P., De Clercq A., Cogniaux-Leclerc J., Nzaramba D., Butzler J. P., Sprecher-Goldberger S. Detection of HIV p17 antigen in lymphocytes but not epithelial cells from cervicovaginal secretions of women seropositive for HIV: implications for heterosexual transmission of the virus. Genitourin Med. 1988 Feb;64(1):30–33. doi: 10.1136/sti.64.1.30. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Vermund S. H., Kelley K. F., Klein R. S., Feingold A. R., Schreiber K., Munk G., Burk R. D. High risk of human papillomavirus infection and cervical squamous intraepithelial lesions among women with symptomatic human immunodeficiency virus infection. Am J Obstet Gynecol. 1991 Aug;165(2):392–400. doi: 10.1016/0002-9378(91)90101-v. [DOI] [PubMed] [Google Scholar]
  28. Vernon S. D., Hart C. E., Reeves W. C., Icenogle J. P. The HIV-1 tat protein enhances E2-dependent human papillomavirus 16 transcription. Virus Res. 1993 Feb;27(2):133–145. doi: 10.1016/0168-1702(93)90077-z. [DOI] [PubMed] [Google Scholar]
  29. Woodworth C. D., Notario V., DiPaolo J. A. Transforming growth factors beta 1 and 2 transcriptionally regulate human papillomavirus (HPV) type 16 early gene expression in HPV-immortalized human genital epithelial cells. J Virol. 1990 Oct;64(10):4767–4775. doi: 10.1128/jvi.64.10.4767-4775.1990. [DOI] [PMC free article] [PubMed] [Google Scholar]
  30. ter Meulen J., Eberhardt H. C., Luande J., Mgaya H. N., Chang-Claude J., Mtiro H., Mhina M., Kashaija P., Ockert S., Yu X. Human papillomavirus (HPV) infection, HIV infection and cervical cancer in Tanzania, east Africa. Int J Cancer. 1992 Jun 19;51(4):515–521. doi: 10.1002/ijc.2910510403. [DOI] [PubMed] [Google Scholar]
  31. zur Hausen H. Viruses in human cancers. Science. 1991 Nov 22;254(5035):1167–1173. doi: 10.1126/science.1659743. [DOI] [PubMed] [Google Scholar]

Articles from The American Journal of Pathology are provided here courtesy of American Society for Investigative Pathology

RESOURCES