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. 1995 Feb;69(2):1349–1352. doi: 10.1128/jvi.69.2.1349-1352.1995

cDNA sequence analysis confirms that the etiologic agent of callitrichid hepatitis is lymphocytic choriomeningitis virus.

C B Stephensen 1, J Y Park 1, S R Blount 1
PMCID: PMC188719  PMID: 7815520

Abstract

Callitrichid hepatitis is an infection of New World primates caused by an arenavirus, currently referred to as callitrichid hepatitis virus, that is closely related to lymphocytic choriomeningitis virus (LCMV). We have cloned and sequenced the GP-C gene of callitrichid hepatitis virus and found that the cDNA sequence is 84 to 86% identical to those of the GP-C genes of LCMV strains Armstrong and WE, while the deduced amino acid sequence is 95 to 96% identical to those of the GP-C gene products of the same strains. This high degree of similarity indicates that the etiologic agent of callitrichid hepatitis is in fact LCMV. The wide geographic distribution of callitrichid hepatitis outbreaks in the United States serves as a reminder that LCMV is also a human pathogen whose public health implications are not well understood.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Borrow P., Oldstone M. B. Characterization of lymphocytic choriomeningitis virus-binding protein(s): a candidate cellular receptor for the virus. J Virol. 1992 Dec;66(12):7270–7281. doi: 10.1128/jvi.66.12.7270-7281.1992. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Chamberlain R. W., Wamwayi H. M., Hockley E., Shaila M. S., Goatley L., Knowles N. J., Barrett T. Evidence for different lineages of rinderpest virus reflecting their geographic isolation. J Gen Virol. 1993 Dec;74(Pt 12):2775–2780. doi: 10.1099/0022-1317-74-12-2775. [DOI] [PubMed] [Google Scholar]
  3. Childs J. E., Glass G. E., Ksiazek T. G., Rossi C. A., Oro J. G., Leduc J. W. Human-rodent contact and infection with lymphocytic choriomeningitis and Seoul viruses in an inner-city population. Am J Trop Med Hyg. 1991 Feb;44(2):117–121. doi: 10.4269/ajtmh.1991.44.117. [DOI] [PubMed] [Google Scholar]
  4. Chomczynski P., Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem. 1987 Apr;162(1):156–159. doi: 10.1006/abio.1987.9999. [DOI] [PubMed] [Google Scholar]
  5. Jahrling P. B., Peters C. J. Lymphocytic choriomeningitis virus. A neglected pathogen of man. Arch Pathol Lab Med. 1992 May;116(5):486–488. [PubMed] [Google Scholar]
  6. Matloubian M., Kolhekar S. R., Somasundaram T., Ahmed R. Molecular determinants of macrophage tropism and viral persistence: importance of single amino acid changes in the polymerase and glycoprotein of lymphocytic choriomeningitis virus. J Virol. 1993 Dec;67(12):7340–7349. doi: 10.1128/jvi.67.12.7340-7349.1993. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Montali R. J., Ramsay E. C., Stephensen C. B., Worley M., Davis J. A., Holmes K. V. A new transmissible viral hepatitis of marmosets and tamarins. J Infect Dis. 1989 Nov;160(5):759–765. doi: 10.1093/infdis/160.5.759. [DOI] [PubMed] [Google Scholar]
  8. Montali R. J., Scanga C. A., Pernikoff D., Wessner D. R., Ward R., Holmes K. V. A common-source outbreak of callitrichid hepatitis in captive tamarins and marmosets. J Infect Dis. 1993 Apr;167(4):946–950. doi: 10.1093/infdis/167.4.946. [DOI] [PubMed] [Google Scholar]
  9. Rota J. S., Hummel K. B., Rota P. A., Bellini W. J. Genetic variability of the glycoprotein genes of current wild-type measles isolates. Virology. 1992 May;188(1):135–142. doi: 10.1016/0042-6822(92)90742-8. [DOI] [PubMed] [Google Scholar]
  10. Rota J. S., Wang Z. D., Rota P. A., Bellini W. J. Comparison of sequences of the H, F, and N coding genes of measles virus vaccine strains. Virus Res. 1994 Mar;31(3):317–330. doi: 10.1016/0168-1702(94)90025-6. [DOI] [PubMed] [Google Scholar]
  11. Stephensen C. B., Blount S. R., Lanford R. E., Holmes K. V., Montali R. J., Fleenor M. E., Shaw J. F. Prevalence of serum antibodies against lymphocytic choriomeningitis virus in selected populations from two U.S. cities. J Med Virol. 1992 Sep;38(1):27–31. doi: 10.1002/jmv.1890380107. [DOI] [PubMed] [Google Scholar]
  12. Stephensen C. B., Jacob J. R., Montali R. J., Holmes K. V., Muchmore E., Compans R. W., Arms E. D., Buchmeier M. J., Lanford R. E. Isolation of an arenavirus from a marmoset with callitrichid hepatitis and its serologic association with disease. J Virol. 1991 Aug;65(8):3995–4000. doi: 10.1128/jvi.65.8.3995-4000.1991. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Stephensen C. B., Montali R. J., Ramsay E. C., Holmes K. V. Identification, using sera from exposed animals, of putative viral antigens in livers of primates with callitrichid hepatitis. J Virol. 1990 Dec;64(12):6349–6354. doi: 10.1128/jvi.64.12.6349-6354.1990. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Weber E. L., Buchmeier M. J. Fine mapping of a peptide sequence containing an antigenic site conserved among arenaviruses. Virology. 1988 May;164(1):30–38. doi: 10.1016/0042-6822(88)90616-2. [DOI] [PubMed] [Google Scholar]

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