Skip to main content
NCBI home page
The American Journal of Pathology logoLink to The American Journal of Pathology
. 1985 Dec;121(3):369–373.

Frequent immunoglobulin and T-cell receptor gene rearrangements in "histiocytic" neoplasms.

L M Weiss, M J Trela, M L Cleary, R R Turner, R A Warnke, J Sklar
PMCID: PMC1887911  PMID: 3907361

Abstract

The authors have analyzed the DNA of immunoglobulin and T-cell receptor genes in a series of 6 malignancies which were judged to be of histiocytic derivation on the basis of morphologic criteria. They found that 4 of these cases showed rearrangements of the beta T-cell receptor genes in spite of the lack of any specific immunohistochemical markers for B or T cells. One case showed rearrangements of both heavy and light chain immunoglobulin genes and probably represents either a sinusoidal large cell lymphoma or a B-cell lymphoma with activation of histiocytes simulating malignant histiocytosis. A single case lacked both immunoglobulin and T-cell receptor rearrangements consistent with immunologic analyses that suggested its origin from an interdigitating reticulum cell. The result of this study in conjunction with the authors' previous immunologic observations suggests that many presumed histiocytic malignancies actually represent T-cell lymphomas. Alternatively, beta T-cell receptor rearrangement may be a common feature of tumors that show monocyte/histiocytic differentiation.

Full text

PDF
369

Images in this article

372Figure 1
on p.372

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Alt F., Rosenberg N., Lewis S., Thomas E., Baltimore D. Organization and reorganization of immunoglobulin genes in A-MULV-transformed cells: rearrangement of heavy but not light chain genes. Cell. 1981 Dec;27(2 Pt 1):381–390. doi: 10.1016/0092-8674(81)90421-9. [DOI] [PubMed] [Google Scholar]
  2. Alwine J. C., Kemp D. J., Stark G. R. Method for detection of specific RNAs in agarose gels by transfer to diazobenzyloxymethyl-paper and hybridization with DNA probes. Proc Natl Acad Sci U S A. 1977 Dec;74(12):5350–5354. doi: 10.1073/pnas.74.12.5350. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Arnold A., Cossman J., Bakhshi A., Jaffe E. S., Waldmann T. A., Korsmeyer S. J. Immunoglobulin-gene rearrangements as unique clonal markers in human lymphoid neoplasms. N Engl J Med. 1983 Dec 29;309(26):1593–1599. doi: 10.1056/NEJM198312293092601. [DOI] [PubMed] [Google Scholar]
  4. Cleary M. L., Chao J., Warnke R., Sklar J. Immunoglobulin gene rearrangement as a diagnostic criterion of B-cell lymphoma. Proc Natl Acad Sci U S A. 1984 Jan;81(2):593–597. doi: 10.1073/pnas.81.2.593. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Cleary M. L., Warnke R., Sklar J. Monoclonality of lymphoproliferative lesions in cardiac-transplant recipients. Clonal analysis based on immunoglobulin-gene rearrangements. N Engl J Med. 1984 Feb 23;310(8):477–482. doi: 10.1056/NEJM198402233100801. [DOI] [PubMed] [Google Scholar]
  6. Feinberg A. P., Vogelstein B. A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. Anal Biochem. 1983 Jul 1;132(1):6–13. doi: 10.1016/0003-2697(83)90418-9. [DOI] [PubMed] [Google Scholar]
  7. Flug F., Pelicci P. G., Bonetti F., Knowles D. M., 2nd, Dalla-Favera R. T-cell receptor gene rearrangements as markers of lineage and clonality in T-cell neoplasms. Proc Natl Acad Sci U S A. 1985 May;82(10):3460–3464. doi: 10.1073/pnas.82.10.3460. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Ha K., Minden M., Hozumi N., Gelfand E. W. Immunoglobulin gene rearrangement in acute myelogenous leukemia. Cancer Res. 1984 Oct;44(10):4658–4660. [PubMed] [Google Scholar]
  9. Hedrick S. M., Cohen D. I., Nielsen E. A., Davis M. M. Isolation of cDNA clones encoding T cell-specific membrane-associated proteins. Nature. 1984 Mar 8;308(5955):149–153. doi: 10.1038/308149a0. [DOI] [PubMed] [Google Scholar]
  10. Hedrick S. M., Nielsen E. A., Kavaler J., Cohen D. I., Davis M. M. Sequence relationships between putative T-cell receptor polypeptides and immunoglobulins. Nature. 1984 Mar 8;308(5955):153–158. doi: 10.1038/308153a0. [DOI] [PubMed] [Google Scholar]
  11. Jaffe E. S., Costa J., Fauci A. S., Cossman J., Tsokos M. Malignant lymphoma and erythrophagocytosis simulating malignant histiocytosis. Am J Med. 1983 Nov;75(5):741–749. doi: 10.1016/0002-9343(83)90402-3. [DOI] [PubMed] [Google Scholar]
  12. Kadin M. E., Kamoun M., Lamberg J. Erythrophagocytic T gamma lymphoma: a clinicopathologic entity resembling malignant histiocytosis. N Engl J Med. 1981 Mar 12;304(11):648–653. doi: 10.1056/NEJM198103123041106. [DOI] [PubMed] [Google Scholar]
  13. Korsmeyer S. J., Arnold A., Bakhshi A., Ravetch J. V., Siebenlist U., Hieter P. A., Sharrow S. O., LeBien T. W., Kersey J. H., Poplack D. G. Immunoglobulin gene rearrangement and cell surface antigen expression in acute lymphocytic leukemias of T cell and B cell precursor origins. J Clin Invest. 1983 Feb;71(2):301–313. doi: 10.1172/JCI110770. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Korsmeyer S. J., Hieter P. A., Ravetch J. V., Poplack D. G., Waldmann T. A., Leder P. Developmental hierarchy of immunoglobulin gene rearrangements in human leukemic pre-B-cells. Proc Natl Acad Sci U S A. 1981 Nov;78(11):7096–7100. doi: 10.1073/pnas.78.11.7096. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. O'Connor N. T., Wainscoat J. S., Weatherall D. J., Gatter K. C., Feller A. C., Isaacson P., Jones D., Lennert K., Pallesen G., Ramsey A. Rearrangement of the T-cell-receptor beta-chain gene in the diagnosis of lymphoproliferative disorders. Lancet. 1985 Jun 8;1(8441):1295–1297. doi: 10.1016/s0140-6736(85)92791-6. [DOI] [PubMed] [Google Scholar]
  16. Osborne B. M., Butler J. J., Mackay B. Sinusoidal large cell ("histiocytic") lymphoma. Cancer. 1980 Dec 1;46(11):2484–2491. doi: 10.1002/1097-0142(19801201)46:11<2484::aid-cncr2820461129>3.0.co;2-p. [DOI] [PubMed] [Google Scholar]
  17. Palumbo A., Minowada J., Erikson J., Croce C. M., Rovera G. Lineage infidelity of a human myelogenous leukemia cell line. Blood. 1984 Nov;64(5):1059–1063. [PubMed] [Google Scholar]
  18. Pettersson U., Sambrook J. Amount of viral DNA in the genome of cells transformed by adenovirus type 2. J Mol Biol. 1973 Jan;73(1):125–130. doi: 10.1016/0022-2836(73)90164-2. [DOI] [PubMed] [Google Scholar]
  19. Rovigatti U., Mirro J., Kitchingman G., Dahl G., Ochs J., Murphy S., Stass S. Heavy chain immunoglobulin gene rearrangement in acute nonlymphocytic leukemia. Blood. 1984 May;63(5):1023–1027. [PubMed] [Google Scholar]
  20. Royer H. D., Bensussan A., Acuto O., Reinherz E. L. Functional isotypes are not encoded by the constant region genes of the beta subunit of the T cell receptor for antigen/major histocompatibility complex. J Exp Med. 1984 Sep 1;160(3):947–952. doi: 10.1084/jem.160.3.947. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Sims J. E., Tunnacliffe A., Smith W. J., Rabbitts T. H. Complexity of human T-cell antigen receptor beta-chain constant- and variable-region genes. Nature. 1984 Dec 6;312(5994):541–545. doi: 10.1038/312541a0. [DOI] [PubMed] [Google Scholar]
  22. Siu G., Clark S. P., Yoshikai Y., Malissen M., Yanagi Y., Strauss E., Mak T. W., Hood L. The human T cell antigen receptor is encoded by variable, diversity, and joining gene segments that rearrange to generate a complete V gene. Cell. 1984 Jun;37(2):393–401. doi: 10.1016/0092-8674(84)90369-6. [DOI] [PubMed] [Google Scholar]
  23. Southern E. M. Detection of specific sequences among DNA fragments separated by gel electrophoresis. J Mol Biol. 1975 Nov 5;98(3):503–517. doi: 10.1016/s0022-2836(75)80083-0. [DOI] [PubMed] [Google Scholar]
  24. Treves A. J., Fuks Z., Voss R., Tal T., Barak V., Konijn A. M., Kaplan R., Laskov R. Establishment of cell lines from somatic cell hybrids between human monocytes and mouse myeloma cells. J Immunol. 1984 Feb;132(2):690–694. [PubMed] [Google Scholar]
  25. Turner R. R., Wood G. S., Beckstead J. H., Colby T. V., Horning S. J., Warnke R. A. Histiocytic malignancies. Morphologic, immunologic, and enzymatic heterogeneity. Am J Surg Pathol. 1984 Jul;8(7):485–500. [PubMed] [Google Scholar]
  26. Weiss L. M., Hu E., Wood G. S., Moulds C., Cleary M. L., Warnke R., Sklar J. Clonal rearrangements of T-cell receptor genes in mycosis fungoides and dermatopathic lymphadenopathy. N Engl J Med. 1985 Aug 29;313(9):539–544. doi: 10.1056/NEJM198508293130903. [DOI] [PubMed] [Google Scholar]
  27. Wood G. S., Warner N. L., Warnke R. A. Anti-Leu-3/T4 antibodies react with cells of monocyte/macrophage and Langerhans lineage. J Immunol. 1983 Jul;131(1):212–216. [PubMed] [Google Scholar]
  28. Wood G. S., Warnke R. A. The immunologic phenotyping of bone marrow biopsies and aspirates: frozen section techniques. Blood. 1982 May;59(5):913–922. [PubMed] [Google Scholar]
  29. Yanagi Y., Yoshikai Y., Leggett K., Clark S. P., Aleksander I., Mak T. W. A human T cell-specific cDNA clone encodes a protein having extensive homology to immunoglobulin chains. Nature. 1984 Mar 8;308(5955):145–149. doi: 10.1038/308145a0. [DOI] [PubMed] [Google Scholar]

Articles from The American Journal of Pathology are provided here courtesy of American Society for Investigative Pathology

RESOURCES