The pathology of experimentally induced cecal amebiasis in gerbils (Meriones unguiculatus). Liver changes and amebic liver abscess formation.

Abstract

The pathogenesis of experimentally induced cecal amebiasis in gerbils (Meriones unguiculatus) was studied from 5 to 60 days after inoculation. Ulcerative lesions were noted 10 to 60 days after inoculation. The sequential development of lesions was asynchronous and progressed from destruction of the interglandular epithelium and of glandular crypt elements to loss of mucosa and formation of granulomatous lesions in the submucosa involving the muscularis mucosae. Pathologic changes in the liver correlated with the formation of ulcerative cecal lesions. Subacute hepatic changes showed lymphocytic portal infiltrate, Kupffer cell hyperplasia, multinucleated giant cells, granuloma formation, and sinusoidal mononuclear and granulocytic infiltrates. Metastatic amebic liver abscesses occurred as early as 10 days after inoculation, and small abscesses were found in the portal areas of the right liver lobe. The sequential development and pathologic manifestation of the infection and the usefulness of the gerbil for the study of human intestinal amebiasis are discussed.

Full text

PDF

• 485
• 486
• 487
• 488
• 489
• …
• 494
• Next

Images in this article

Figure 1
on p.487

Figure 2
on p.487

Figure 3
on p.487

Figure 4
on p.487

Figure 5
on p.489

Figure 6
on p.489

Figure 7
on p.489

Figure 8
on p.489

Figure 9
on p.491

Figure 10
on p.491

Figure 11
on p.491

Figure 12
on p.491

Figure 13
on p.491

Figure 14
on p.491

Figure 15
on p.493

Figure 16
on p.493

Figure 17
on p.493

Figure 18
on p.493