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. 1986 Feb;122(2):199–203.

L&H variants of Reed-Sternberg cells express sialylated Leu M1 antigen.

S M Hsu, Y S Ho, P J Li, J Monheit, H J Ree, K Sheibani, C D Winberg
PMCID: PMC1888104  PMID: 3511719

Abstract

Anti-Leu M1 generally does not stain the lymphocytic and histiocytic (L&H) variants of Reed-Sternberg cells in the lymphocyte predominant type of Hodgkin's disease. However, the authors found that after neuraminidase treatment for removal of sialic acid, the L&H cells in more than half of the cases studied could be stained by anti-Leu M1. This result strongly suggests that L&H cells differ from the Reed-Sternberg cells in other types of Hodgkin's disease in their unique capacity to sialylate the 150-kd Leu M1 antigen.

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Selected References

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  1. Abdulaziz Z., Mason D. Y., Stein H., Gatter K. C., Nash J. R. An immunohistological study of the cellular constituents of Hodgkin's disease using a monoclonal antibody panel. Histopathology. 1984 Jan;8(1):1–25. doi: 10.1111/j.1365-2559.1984.tb02318.x. [DOI] [PubMed] [Google Scholar]
  2. Beckstead J. H., Warnke R., Bainton D. F. Histochemistry of Hodgkin's disease. Cancer Treat Rep. 1982 Apr;66(4):609–613. [PubMed] [Google Scholar]
  3. Chatterjee S., Gupta P., Pyeritz R. E., Kwiterovich P. O., Jr Immunohistochemical localization of glycosphingolipid in urinary renal tubular cells in Fabry's disease. Am J Clin Pathol. 1984 Jul;82(1):24–28. doi: 10.1093/ajcp/82.1.24. [DOI] [PubMed] [Google Scholar]
  4. Diehl V., Kirchner H. H., Burrichter H., Stein H., Fonatsch C., Gerdes J., Schaadt M., Heit W., Uchanska-Ziegler B., Ziegler A. Characteristics of Hodgkin's disease-derived cell lines. Cancer Treat Rep. 1982 Apr;66(4):615–632. [PubMed] [Google Scholar]
  5. Hanjan S. N., Kearney J. F., Cooper M. D. A monoclonal antibody (MMA) that identifies a differentiation antigen on human myelomonocytic cells. Clin Immunol Immunopathol. 1982 May;23(2):172–188. doi: 10.1016/0090-1229(82)90106-4. [DOI] [PubMed] [Google Scholar]
  6. Hecht T. T., Longo D. L., Cossman J., Bolen J. B., Hsu S. M., Israel M., Fisher R. I. Production and characterization of a monoclonal antibody that binds Reed-Sternberg cells. J Immunol. 1985 Jun;134(6):4231–4236. [PubMed] [Google Scholar]
  7. Hsu S. M., Yang K., Jaffe E. S. Phenotypic expression of Hodgkin's and Reed-Sternberg cells in Hodgkin's disease. Am J Pathol. 1985 Feb;118(2):209–217. [PMC free article] [PubMed] [Google Scholar]
  8. Kadin M. E. Possible origin of the Reed-Sternberg cell from an interdigitating reticulum cell. Cancer Treat Rep. 1982 Apr;66(4):601–608. [PubMed] [Google Scholar]
  9. Kaplan H. S. On the biology and immunology of Hodgkin's disease. Haematol Blood Transfus. 1981;26:11–23. doi: 10.1007/978-3-642-67984-1_2. [DOI] [PubMed] [Google Scholar]
  10. Miettinen M., Franssila K. O., Saxén E. Hodgkin's disease, lymphocytic predominance nodular. Increased risk for subsequent non-Hodgkin's lymphomas. Cancer. 1983 Jun 15;51(12):2293–2300. doi: 10.1002/1097-0142(19830615)51:12<2293::aid-cncr2820511221>3.0.co;2-x. [DOI] [PubMed] [Google Scholar]
  11. Olsson L. On the natural biology of the malignant cells in Hodgkin's disease. Int J Radiat Oncol Biol Phys. 1985 Jan;11(1):37–48. doi: 10.1016/0360-3016(85)90360-8. [DOI] [PubMed] [Google Scholar]
  12. Pinkus G. S., Said J. W. Hodgkin's disease, lymphocyte predominance type, nodular--a distinct entity? Unique staining profile for L&H variants of Reed-Sternberg cells defined by monoclonal antibodies to leukocyte common antigen, granulocyte-specific antigen, and B-cell-specific antigen. Am J Pathol. 1985 Jan;118(1):1–6. [PMC free article] [PubMed] [Google Scholar]
  13. Pinkus G. S., Thomas P., Said J. W. Leu-M1--a marker for Reed-Sternberg cells in Hodgkin's disease. An immunoperoxidase study of paraffin-embedded tissues. Am J Pathol. 1985 May;119(2):244–252. [PMC free article] [PubMed] [Google Scholar]
  14. Poppema S., Kaiserling E., Lennert K. Hodgkin's disease with lymphocytic predominance, nodular type (nodular paragranuloma) and progressively transformed germinal centres--a cytohistological study. Histopathology. 1979 Jul;3(4):295–308. doi: 10.1111/j.1365-2559.1979.tb03011.x. [DOI] [PubMed] [Google Scholar]
  15. Poppema S., Kaiserling E., Lennert K. Nodular paragranuloma and progressively transformed germinal centers. Ultrastructural and immunohistologic findings. Virchows Arch B Cell Pathol Incl Mol Pathol. 1979;31(3):211–225. doi: 10.1007/BF02889938. [DOI] [PubMed] [Google Scholar]
  16. Poppema S. The diversity of the immunohistological staining pattern of Sternberg-Reed cells. J Histochem Cytochem. 1980 Aug;28(8):788–791. doi: 10.1177/28.8.6777426. [DOI] [PubMed] [Google Scholar]
  17. Schwab U., Stein H., Gerdes J., Lemke H., Kirchner H., Schaadt M., Diehl V. Production of a monoclonal antibody specific for Hodgkin and Sternberg-Reed cells of Hodgkin's disease and a subset of normal lymphoid cells. Nature. 1982 Sep 2;299(5878):65–67. doi: 10.1038/299065a0. [DOI] [PubMed] [Google Scholar]
  18. Speckart S. F., Boldt D. H., MacDermott R. P. Chronic lymphatic leukemia (CLL): cell surface changes detected by lectin binding and their relation to altered glycosyltransferase activity. Blood. 1978 Oct;52(4):681–695. [PubMed] [Google Scholar]

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