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. 1995 Mar;69(3):1955–1958. doi: 10.1128/jvi.69.3.1955-1958.1995

Interleukin-12 gene expression after viral infection in the mouse.

J P Coutelier 1, J Van Broeck 1, S F Wolf 1
PMCID: PMC188815  PMID: 7853541

Abstract

Interleukin-12 is a lymphokine that triggers gamma interferon secretion by various cells and differentiation of T-helper lymphocytes towards the Th1 subtype. Since viruses are potent inducers of gamma interferon production and elicit immune responses most probably mediated by Th1 cells, like B-cell immunoglobulin G2a secretion, we analyzed interleukin-12 message expression after infection of mice with lactate dehydrogenase-elevating virus, mouse hepatitis virus, and mouse adenovirus. Our results indicated that the message for the p40 component of interleukin-12 was transiently increased shortly after infection. Interleukin-12 was expressed mainly by macrophages. Therefore, production of interleukin-12 might constitute the initial event that would determine the subsequent characteristics of the immune response elicited by viral infections.

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Selected References

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