Skip to main content
PMC home page
The American Journal of Pathology logoLink to The American Journal of Pathology
. 1986 Mar;122(3):392–397.

Clonal T-cell populations in angioimmunoblastic lymphadenopathy and angioimmunoblastic lymphadenopathy-like lymphoma.

L M Weiss, J G Strickler, R F Dorfman, S J Horning, R A Warnke, J Sklar
PMCID: PMC1888223  PMID: 3082212

Abstract

Ten cases of angioimmunoblastic lymphadenopathy with dysproteinemia (AILD) and AILD-like lymphoma were studied by immunophenotypic and immunogenotypic analysis. All specimens were found to have a predominance of T cells by immunophenotypic analysis. DNA hybridization analyses showed three of five specimens of AILD and five of six specimens of AILD-like lymphoma to contain clonal rearrangements of the beta T-cell receptor gene. No rearrangements of the heavy or light chain immunoglobulin genes were seen in any case. A single case showed a progression of AILD with a germ-line pattern of beta T-cell receptor DNA to AILD-like lymphoma with detectable clonal rearrangements for beta T-cell receptor DNA. These results suggest that many, but not all, cases diagnosed histologically as AILD or AILD-like lymphoma contain a clonal proliferation of T-lymphocytes.

Full text

PDF
392

Images in this article

395Figure 1
on p.395
396Figure 2
on p.396

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Alwine J. C., Kemp D. J., Stark G. R. Method for detection of specific RNAs in agarose gels by transfer to diazobenzyloxymethyl-paper and hybridization with DNA probes. Proc Natl Acad Sci U S A. 1977 Dec;74(12):5350–5354. doi: 10.1073/pnas.74.12.5350. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Bertness V., Kirsch I., Hollis G., Johnson B., Bunn P. A., Jr T-cell receptor gene rearrangements as clinical markers of human T-cell lymphomas. N Engl J Med. 1985 Aug 29;313(9):534–538. doi: 10.1056/NEJM198508293130902. [DOI] [PubMed] [Google Scholar]
  3. Cleary M. L., Chao J., Warnke R., Sklar J. Immunoglobulin gene rearrangement as a diagnostic criterion of B-cell lymphoma. Proc Natl Acad Sci U S A. 1984 Jan;81(2):593–597. doi: 10.1073/pnas.81.2.593. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Feinberg A. P., Vogelstein B. A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. Anal Biochem. 1983 Jul 1;132(1):6–13. doi: 10.1016/0003-2697(83)90418-9. [DOI] [PubMed] [Google Scholar]
  5. Fisher R. I., Jaffe E. S., Braylan R. C., Andersen J. C., Tan H. K. Immunoblastic lymphadenopathy. Evolution into a malignant lymphoma with plasmacytoid features. Am J Med. 1976 Oct;61(4):553–559. doi: 10.1016/0002-9343(76)90337-5. [DOI] [PubMed] [Google Scholar]
  6. Frizzera G., Moran E. M., Rappaport H. Angio-immunoblastic lymphadenopathy with dysproteinaemia. Lancet. 1974 Jun 1;1(7866):1070–1073. doi: 10.1016/s0140-6736(74)90553-4. [DOI] [PubMed] [Google Scholar]
  7. Frizzera G., Moran E. M., Rappaport H. Angio-immunoblastic lymphadenopathy. Diagnosis and clinical course. Am J Med. 1975 Dec;59(6):803–818. doi: 10.1016/0002-9343(75)90466-0. [DOI] [PubMed] [Google Scholar]
  8. Hossfeld D. K., Höffken K., Schmidt C. G., Diedrichs H. Letter: Chromosome abnormalities in angioimmunoblastic lymphadenopathy. Lancet. 1976 Jan 24;1(7952):198–198. doi: 10.1016/s0140-6736(76)91308-8. [DOI] [PubMed] [Google Scholar]
  9. Howarth C. B., Bird C. C. Immunoblastic sarcoma arising in child with immunoblastic lymphadenopathy. Lancet. 1976 Oct 2;2(7988):747–748. doi: 10.1016/s0140-6736(76)90049-0. [DOI] [PubMed] [Google Scholar]
  10. Knowles D. M., Dalla-Favera R., Pelicci P. G. T-cell-receptor beta-chain gene rearrangements. Lancet. 1985 Jul 20;2(8447):159–160. doi: 10.1016/s0140-6736(85)90267-3. [DOI] [PubMed] [Google Scholar]
  11. Krueger G. R., Bergholz M., Bartsch H. H., Fischer R., Schauer A. Rubella virus antigen in lymphocytes of patients with angioimmunoblastic lymphadenopathy (AIL). J Cancer Res Clin Oncol. 1979 Sep;95(1):87–91. doi: 10.1007/BF00411114. [DOI] [PubMed] [Google Scholar]
  12. Lukes R. J., Tindle B. H. Immunoblastic lymphadenopathy. A hyperimmune entity resembling Hodgkin's disease. N Engl J Med. 1975 Jan 2;292(1):1–8. doi: 10.1056/NEJM197501022920101. [DOI] [PubMed] [Google Scholar]
  13. Lukes R. J., Tindle B. H. Immunoblastic lymphadenopathy: a prelymphomatous state of immunoblastic sarcoma. Recent Results Cancer Res. 1978;64:241–246. doi: 10.1007/978-3-642-81246-0_28. [DOI] [PubMed] [Google Scholar]
  14. Nathwani B. N., Rappaport H., Moran E. M., Pangalis G. A., Kim H. Malignant lymphoma arising in angioimmunoblastic lymphadenopathy. Cancer. 1978 Feb;41(2):578–606. doi: 10.1002/1097-0142(197802)41:2<578::aid-cncr2820410226>3.0.co;2-8. [DOI] [PubMed] [Google Scholar]
  15. O'Connor N. T., Wainscoat J. S., Weatherall D. J., Gatter K. C., Feller A. C., Isaacson P., Jones D., Lennert K., Pallesen G., Ramsey A. Rearrangement of the T-cell-receptor beta-chain gene in the diagnosis of lymphoproliferative disorders. Lancet. 1985 Jun 8;1(8441):1295–1297. doi: 10.1016/s0140-6736(85)92791-6. [DOI] [PubMed] [Google Scholar]
  16. Pettersson U., Sambrook J. Amount of viral DNA in the genome of cells transformed by adenovirus type 2. J Mol Biol. 1973 Jan;73(1):125–130. doi: 10.1016/0022-2836(73)90164-2. [DOI] [PubMed] [Google Scholar]
  17. Southern E. M. Detection of specific sequences among DNA fragments separated by gel electrophoresis. J Mol Biol. 1975 Nov 5;98(3):503–517. doi: 10.1016/s0022-2836(75)80083-0. [DOI] [PubMed] [Google Scholar]
  18. Weiss L. M., Crabtree G. S., Rouse R. V., Warnke R. A. Morphologic and immunologic characterization of 50 peripheral T-cell lymphomas. Am J Pathol. 1985 Feb;118(2):316–324. [PMC free article] [PubMed] [Google Scholar]
  19. Weiss L. M., Hu E., Wood G. S., Moulds C., Cleary M. L., Warnke R., Sklar J. Clonal rearrangements of T-cell receptor genes in mycosis fungoides and dermatopathic lymphadenopathy. N Engl J Med. 1985 Aug 29;313(9):539–544. doi: 10.1056/NEJM198508293130903. [DOI] [PubMed] [Google Scholar]
  20. Wood G. S., Warnke R. A. The immunologic phenotyping of bone marrow biopsies and aspirates: frozen section techniques. Blood. 1982 May;59(5):913–922. [PubMed] [Google Scholar]

Articles from The American Journal of Pathology are provided here courtesy of American Society for Investigative Pathology

RESOURCES