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. 1986 Aug;124(2):193–198.

Contrasting features of T-lymphocyte-mediated diabetes in encephalomyocarditis virus-infected Balb/cBy and Balb/cCum mice.

P G Babu, S A Huber, J E Craighead
PMCID: PMC1888285  PMID: 3017115

Abstract

Two closely related sublines of the Balb/c strain, Balb/cBy and Balb/cCum mice respond differently when inoculated with the diabetogenic M variant of the encephalomyocarditis (EMCM) virus. Although genetically similar, Balb/cBy mice develop severe hyperglycemia, whereas Balb/cCum animals exhibit only modest alterations in glucose tolerance. Virus concentrations in the pancreases of animals of both sublines are equivalent 3 days after inoculation and decrease rapidly to undetectable levels within 10 days, at a time when hyperglycemia in Balb/cBy mice peaks. These results support two conclusions: 1) direct virus-induced injury to the beta cells probably is not responsible for hyperglycemia in Balb/c mice, and 2) virus replication in the pancreas does not predict diabetes susceptibility. Diabetes in Balb/cBy mice is immunologically mediated. These animals generate cytolytic T lymphocytes specific for beta cells during periods corresponding to glucose intolerance, and anti-thymocyte serum treatment of infected mice prevents the development of hyperglycemia. The pathogenesis of diabetes in Balb/cCum mice is not clear. Although cytolytic T cells appear concomitant with glucose intolerance, anti-thymocyte serum has not consistently prevented the development of the metabolic disease.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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