Abstract
The effects of disturbances of the pulmonary circulation on the formation of pulmonary emphysematous bullae in rabbits were studied with the use of changes in the parenchyma of lungs insulted by both pulmonary embolization with Sephadex beads and carrageenan-induced pneumonia. Rabbits given one of the larger doses of Sephadex and then carrageenan in solution had giant bullous lesions in the lobe treated with those agents 2 months later. More animals had bullous lesions in the groups given the larger doses of Sephadex than in groups given the smallest dose or none. In animals killed after 2 weeks, bullous lesions were found, whereas there were none in those killed after 1 week. These results suggest that the size and number of bullous lesions forming in the treated lobes are associated with the dose of Sephadex. Giant and small bullous lesions are varieties of the same disorder, and there seems to be a latent period for development.
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- ALARCON D. G. Regressive giant bullous emphysema in tuberculosis of adults. Dis Chest. 1955 Jan;27(1):31–43. doi: 10.1378/chest.27.1.31. [DOI] [PubMed] [Google Scholar]
- CRENSHAW G. L. Degenerative lung disease. Dis Chest. 1954 Apr;25(4):427–442. doi: 10.1378/chest.25.4.427. [DOI] [PubMed] [Google Scholar]
- Fain W. R., Conn J. H., Campbell G. D., Chavez C. M., Gee H. L., Hardy J. D. Excision of giant pulmonary emphysematous cysts: report of 20 cases without deaths. Surgery. 1967 Sep;62(3):552–559. [PubMed] [Google Scholar]
- Iwa T., Watanabe Y., Fukatani G. Simultaneous bilateral operations for bullous emphysema by median sternotomy. J Thorac Cardiovasc Surg. 1981 May;81(5):732–737. [PubMed] [Google Scholar]
- Kuhn C., 3rd, Starcher B. C. The effect of lathyrogens on the evolution of elastase-induced emphysema. Am Rev Respir Dis. 1980 Sep;122(3):453–460. doi: 10.1164/arrd.1980.122.3.453. [DOI] [PubMed] [Google Scholar]
- Lichter I., Gwynne J. F. Spontaneous pneumothorax in young subjects. A clinical and pathological study. Thorax. 1971 Jul;26(4):409–417. doi: 10.1136/thx.26.4.409. [DOI] [PMC free article] [PubMed] [Google Scholar]
- McGoldrick P. J., Rudd T. G., Figley M. M., Wilhelm J. P. What becomes of pulmonary infarcts? AJR Am J Roentgenol. 1979 Dec;133(6):1039–1045. doi: 10.2214/ajr.133.6.1039. [DOI] [PubMed] [Google Scholar]
- Mitsuhashi T., Arai R., Sawa H. Right ventricular hypertrophy following chronic pulmonary embolism induced by repeated administration of Sephadex particles. Tohoku J Exp Med. 1980 Jun;131(2):143–150. doi: 10.1620/tjem.131.143. [DOI] [PubMed] [Google Scholar]
- Mitsuhashi T., Chanoki Y., Kuwahara H., Sakai T., Masuda H., Sugino S. Experimental emphysematous bullae induced by methylcholanthrene and carrageenan. Tohoku J Exp Med. 1985 Mar;145(3):341–351. doi: 10.1620/tjem.145.341. [DOI] [PubMed] [Google Scholar]
- Mitsuhashi T., Shimazaki M., Sugino S., Takeda T., Inariba H. Morphological studies on proliferation and desquamation of the alveolar lining epithelium in carrageenan-induced experimental pneumonia. Tohoku J Exp Med. 1983 Jul;140(3):319–330. doi: 10.1620/tjem.140.319. [DOI] [PubMed] [Google Scholar]
- Mitsuhashi T., Sugino S., Shimazaki M., Chanoki Y., Kuwahara H. Experimental emphysematous bullae. Lung. 1984;162(3):165–170. doi: 10.1007/BF02715644. [DOI] [PubMed] [Google Scholar]
- Niewoehner D. E., Hoidal J. R. Lung fibrosis and emphysema: divergent responses to a common injury? Science. 1982 Jul 23;217(4557):359–360. doi: 10.1126/science.7089570. [DOI] [PubMed] [Google Scholar]
- ROACH H. D., LAUFMAN H. Relationship between pulmonary embolism and pulmonary embolism and pulmonary infarction: an experimental study. Ann Surg. 1955 Jul;142(1):82–91. doi: 10.1097/00000658-195507000-00010. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Soskel N. T., Watanabe S., Sandberg L. B. Mechanisms of lung injury in the copper-deficient hamster model of emphysema. Chest. 1984 Jun;85(6 Suppl):70S–73S. doi: 10.1378/chest.85.6_supplement.70s. [DOI] [PubMed] [Google Scholar]