Skip to main content
NCBI home page
The American Journal of Pathology logoLink to The American Journal of Pathology
. 1986 Sep;124(3):412–419.

The extracellular matrix of pulmonary scar carcinomas is suggestive of a desmoplastic origin.

S H Barsky, S J Huang, S Bhuta
PMCID: PMC1888343  PMID: 3766702

Abstract

Pulmonary scar carcinomas and noncarcinomatous apical scars were subjected to collagen extraction, ultrastructural, and immunocytochemical studies designed to investigate the nature of their extracellular matrix. These studies revealed marked differences in both cellular and biochemical composition of scar carcinomas, compared with apical scars. Myofibroblasts, identified by antimyosin antibodies and confirmed by electron microscopy, constituted over 90% of the stromal cells of the scar carcinomas, compared with 0-10% in the apical scars. Collagen extraction studies revealed both an absolute and relative increase in Type V collagen in the scar carcinomas, compared with that found in the apical scars. The extracellular matrix of the pulmonary scar carcinomas was, however, identical to that of scirrhous carcinomas of the breast. These findings suggest that pulmonary scar carcinomas are probably desmoplastic carcinomas, rather than scar-arising tumors.

Full text

PDF
412

Images in this article

414Figure 1
on p.414
415Figure 2
on p.415
416Figure 3
on p.416

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Auerbach O., Garfinkel L., Parks V. R. Scar cancer of the lung: increase over a 21 year period. Cancer. 1979 Feb;43(2):636–642. doi: 10.1002/1097-0142(197902)43:2<636::aid-cncr2820430234>3.0.co;2-7. [DOI] [PubMed] [Google Scholar]
  2. Barsky S. H., Green W. R., Grotendorst G. R., Liotta L. A. Desmoplastic breast carcinoma as a source of human myofibroblasts. Am J Pathol. 1984 Jun;115(3):329–333. [PMC free article] [PubMed] [Google Scholar]
  3. Barsky S. H., Rao C. N., Grotendorst G. R., Liotta L. A. Increased content of Type V Collagen in desmoplasia of human breast carcinoma. Am J Pathol. 1982 Sep;108(3):276–283. [PMC free article] [PubMed] [Google Scholar]
  4. Brownstein M. H., Shapiro L. Desmoplastic trichoepithelioma. Cancer. 1977 Dec;40(6):2979–2986. doi: 10.1002/1097-0142(197712)40:6<2979::aid-cncr2820400633>3.0.co;2-8. [DOI] [PubMed] [Google Scholar]
  5. Chaudhuri M. R. Primary pulmonary scar carcinomas. Indian J Med Res. 1973 Jun;61(6):858–863. [PubMed] [Google Scholar]
  6. Ehrlich H. P., White B. S. The identification of alpha A and alpha B collagen chains in hypertrophic scar. Exp Mol Pathol. 1981 Feb;34(1):1–8. doi: 10.1016/0014-4800(81)90030-7. [DOI] [PubMed] [Google Scholar]
  7. Fox B., Risdon R. A. Carcinoma of the lung and diffuse interstitial pulmonary fibrosis. J Clin Pathol. 1968 Jul;21(4):486–491. doi: 10.1136/jcp.21.4.486. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. GELZER J. Uber die peripheren Lungenkrebse im Bereich von Lungennarben; Beobachtungen am Basler Pathologischen Institut von 1938-1954. Virchows Arch Pathol Anat Physiol Klin Med. 1956;329(4):504–520. doi: 10.1007/BF00956202. [DOI] [PubMed] [Google Scholar]
  9. Gabbiani G., Hirschel B. J., Ryan G. B., Statkov P. R., Majno G. Granulation tissue as a contractile organ. A study of structure and function. J Exp Med. 1972 Apr 1;135(4):719–734. doi: 10.1084/jem.135.4.719. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Gabbiani G., Le Lous M., Bailey A. J., Bazin S., Delaunay A. Collagen and myofibroblasts of granulation tissue. A chemical, ultrastructural and immunologic study. Virchows Arch B Cell Pathol. 1976 Aug 11;21(2):133–145. doi: 10.1007/BF02899150. [DOI] [PubMed] [Google Scholar]
  11. Gabbiani G., Ryan G. B., Majne G. Presence of modified fibroblasts in granulation tissue and their possible role in wound contraction. Experientia. 1971 May 15;27(5):549–550. doi: 10.1007/BF02147594. [DOI] [PubMed] [Google Scholar]
  12. Gray R. E., O'Neal R. M. Multiple pulmonary scar carcinomas in a patient with Hodgkin's disease: report of a case and review of the literature. Cancer. 1980 Oct 15;46(8):1868–1872. doi: 10.1002/1097-0142(19801015)46:8<1868::aid-cncr2820460827>3.0.co;2-k. [DOI] [PubMed] [Google Scholar]
  13. Kitagawa M. Autopsy study of lung cancer with special reference to scar cancer. Acta Pathol Jpn. 1965 May;15(2):199–222. [PubMed] [Google Scholar]
  14. Limas C., Japaze H., Garcia-Bunuel R. "Scar" carcinoma of the lung. Chest. 1971 Feb;59(2):219–222. doi: 10.1378/chest.59.2.219. [DOI] [PubMed] [Google Scholar]
  15. MEYER E. C., LIEBOW A. A. RELATIONSHIP OF INTERSTITIAL PNEUMONIA HONEYCOMBING AND ATYPICAL EPITHELIAL PROLIFERATION TO CANCER OF THE LUNG. Cancer. 1965 Mar;18:322–351. doi: 10.1002/1097-0142(196503)18:3<322::aid-cncr2820180310>3.0.co;2-j. [DOI] [PubMed] [Google Scholar]
  16. Madri J. A., Carter D. Scar cancers of the lung: origin and significance. Hum Pathol. 1984 Jul;15(7):625–631. doi: 10.1016/s0046-8177(84)80286-5. [DOI] [PubMed] [Google Scholar]
  17. Majno G. The story of the myofibroblasts. Am J Surg Pathol. 1979 Dec;3(6):535–542. doi: 10.1097/00000478-197912000-00006. [DOI] [PubMed] [Google Scholar]
  18. RAEBURN B., SPENCER H. Lung scar cancers. Br J Tuberc Dis Chest. 1957 Jul;51(3):237–245. doi: 10.1016/s0366-0869(57)80080-x. [DOI] [PubMed] [Google Scholar]
  19. RAEBURN C., SPENCER H. A study of the origin and development of lung cancer. Thorax. 1953 Mar;8(1):1–10. doi: 10.1136/thx.8.1.1. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Rhodes R. K., Miller E. J. Physicochemical characterization and molecular organization of the collagen A and B chains. Biochemistry. 1978 Aug 22;17(17):3442–3448. doi: 10.1021/bi00610a003. [DOI] [PubMed] [Google Scholar]
  21. Schürch W., Lagacé R., Seemayer T. A. Myofibroblastic stromal reaction in retracted scirrhous carcinoma of the breast. Surg Gynecol Obstet. 1982 Mar;154(3):351–358. [PubMed] [Google Scholar]
  22. Schürch W., Seemayer T. A., Lagacé R. Stromal myofibroblasts in primary invasive and metastatic carcinomas. A combined immunological, light and electron microscopic study. Virchows Arch A Pathol Anat Histol. 1981;391(2):125–139. doi: 10.1007/BF00437591. [DOI] [PubMed] [Google Scholar]
  23. Seemayer T. A., Lagacé R., Schürch W., Tremblay G. Myofibroblasts in the stroma of invasive and metastatic carcinoma: a possible host response to neoplasia. Am J Surg Pathol. 1979 Dec;3(6):525–533. doi: 10.1097/00000478-197912000-00005. [DOI] [PubMed] [Google Scholar]
  24. Seemayer T. A., Schürch W., Lagacé R. Myofibroblasts in human pathology. Hum Pathol. 1981 Jun;12(6):491–492. doi: 10.1016/s0046-8177(81)80061-5. [DOI] [PubMed] [Google Scholar]
  25. Shimosato Y., Suzuki A., Hashimoto T., Nishiwaki Y., Kodama T., Yoneyama T., Kameya T. Prognostic implications of fibrotic focus (scar) in small peripheral lung cancers. Am J Surg Pathol. 1980 Aug;4(4):365–373. doi: 10.1097/00000478-198008000-00005. [DOI] [PubMed] [Google Scholar]
  26. Tremblay G. Elastosis in tubular carcinoma of the breast. Arch Pathol. 1974 Nov;98(5):302–307. [PubMed] [Google Scholar]
  27. Tremblay G. Stromal aspects of breast carcinoma. Exp Mol Pathol. 1979 Aug;31(1):248–260. doi: 10.1016/0014-4800(79)90026-1. [DOI] [PubMed] [Google Scholar]
  28. Tremblay G. Ultrastructure of elastosis in scirrhous carcinoma of the breast. Cancer. 1976 Jan;37(1):307–316. doi: 10.1002/1097-0142(197601)37:1<307::aid-cncr2820370141>3.0.co;2-c. [DOI] [PubMed] [Google Scholar]
  29. Valensi Q. J. Desmoplastic malignant melanoma: A light and electron microscopic study of two cases. Cancer. 1979 Mar;43(3):1148–1155. doi: 10.1002/1097-0142(197903)43:3<1148::aid-cncr2820430355>3.0.co;2-n. [DOI] [PubMed] [Google Scholar]
  30. WOESSNER J. F., Jr The determination of hydroxyproline in tissue and protein samples containing small proportions of this imino acid. Arch Biochem Biophys. 1961 May;93:440–447. doi: 10.1016/0003-9861(61)90291-0. [DOI] [PubMed] [Google Scholar]
  31. YOKOO H., SUCKOW E. E. Peripheral lung cancers arising in scars. Cancer. 1961 Nov-Dec;14:1205–1215. doi: 10.1002/1097-0142(196111/12)14:6<1205::aid-cncr2820140610>3.0.co;2-2. [DOI] [PubMed] [Google Scholar]
  32. de Lanerolle P., Stull J. T. Myosin phosphorylation during contraction and relaxation of tracheal smooth muscle. J Biol Chem. 1980 Oct 25;255(20):9993–10000. [PubMed] [Google Scholar]

Articles from The American Journal of Pathology are provided here courtesy of American Society for Investigative Pathology

RESOURCES