Abstract
Women with culture-proven Chlamydia trachomatis cervical infection were randomized to receive either ofloxacin (300 mg) or doxycycline (100 mg), orally twice daily for 7 days. All 56 had negative cultures 5 to 9 days after treatment. Four weeks after treatment, 26 (93%) of 28 ofloxacin-treated patients and all 22 doxycycline-treated patients were cured. We conclude that 300 mg of ofloxacin given twice daily for 7 days provides effective therapy for chlamydial infection of the cervix.
Full text
PDF


Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Brunham R. C., Paavonen J., Stevens C. E., Kiviat N., Kuo C. C., Critchlow C. W., Holmes K. K. Mucopurulent cervicitis--the ignored counterpart in women of urethritis in men. N Engl J Med. 1984 Jul 5;311(1):1–6. doi: 10.1056/NEJM198407053110101. [DOI] [PubMed] [Google Scholar]
- Chandeying V., Sutthijumroon S., Tungphaisal S. Evaluation of ofloxacin in the treatment of mucopurulent cervicitis: response of chlamydia-positive and chlamydia-negative forms. J Med Assoc Thai. 1989 Jun;72(6):331–337. [PubMed] [Google Scholar]
- Hooper D. C., Wolfson J. S. Treatment of genitourinary tract infections with fluoroquinolones: clinical efficacy in genital infections and adverse effects. Antimicrob Agents Chemother. 1989 Oct;33(10):1662–1667. doi: 10.1128/aac.33.10.1662. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hooton T. M., Rogers M. E., Medina T. G., Kuwamura L. E., Ewers C., Roberts P. L., Stamm W. E. Ciprofloxacin compared with doxycycline for nongonococcal urethritis. Ineffectiveness against Chlamydia trachomatis due to relapsing infection. JAMA. 1990 Sep 19;264(11):1418–1421. [PubMed] [Google Scholar]
- Kitchen V. S., Donegan C., Ward H., Thomas B., Harris J. R., Taylor-Robinson D. Comparison of ofloxacin with doxycycline in the treatment of non-gonococcal urethritis and cervical chlamydial infection. J Antimicrob Chemother. 1990 Nov;26 (Suppl 500):99–105. doi: 10.1093/jac/26.suppl_d.99. [DOI] [PubMed] [Google Scholar]
- Mogabgab W. J., Holmes B., Murray M., Beville R., Lutz F. B., Tack K. J. Randomized comparison of ofloxacin and doxycycline for chlamydia and ureaplasma urethritis and cervicitis. Chemotherapy. 1990;36(1):70–76. doi: 10.1159/000238750. [DOI] [PubMed] [Google Scholar]
- Nayagam A. T., Ridgway G. L., Oriel J. D. Efficacy of ofloxacin in the treatment of non-gonococcal urethritis in men and genital infections caused by Chlamydia trachomatis in men and women. J Antimicrob Chemother. 1988 Sep;22 (Suppl 100):155–158. doi: 10.1093/jac/22.supplement_c.155. [DOI] [PubMed] [Google Scholar]
- Wolfson J. S., Hooper D. C. Treatment of genitourinary tract infections with fluoroquinolones: activity in vitro, pharmacokinetics, and clinical efficacy in urinary tract infections and prostatitis. Antimicrob Agents Chemother. 1989 Oct;33(10):1655–1661. doi: 10.1128/aac.33.10.1655. [DOI] [PMC free article] [PubMed] [Google Scholar]