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. 1995 Apr;69(4):2684–2688. doi: 10.1128/jvi.69.4.2684-2688.1995

DNA immunization confers protection against lethal lymphocytic choriomeningitis virus infection.

M Yokoyama 1, J Zhang 1, J L Whitton 1
PMCID: PMC188955  PMID: 7884923

Abstract

DNA vaccination has been evaluated with the lymphocytic choriomeningitis virus (LCMV) model system. Plasmid DNA encoding the LCMV nucleoprotein, when injected intramuscularly, induces both antiviral antibodies and cytotoxic T lymphocytes. Injection of DNA encoding the nucleoprotein or the viral glycoprotein confers protection against normally lethal LCMV challenge in a major histocompatibility complex-dependent manner. The protection conferred is incomplete, but it is most probably mediated by the induced cytotoxic T lymphocytes.

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Selected References

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