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. 1995 Jun;69(6):3273–3281. doi: 10.1128/jvi.69.6.3273-3281.1995

Dual human immunodeficiency virus type 1 infection and recombination in a dually exposed transfusion recipient. The Transfusion Safety Study Group.

R S Diaz 1, E C Sabino 1, A Mayer 1, J W Mosley 1, M P Busch 1
PMCID: PMC189038  PMID: 7745674

Abstract

We studied a case in which a 2-month-old premature infant was concurrently transfused with packed erythrocytes from two different human immunodeficiency virus type 1 (HIV-1)-seropositive donors in late 1984. The two donors also each singly infected a second infant. Inspection of sequences from portions of the HIV-1 genomes in each of the two donors showed a close relationship to the strain in their respective singly exposed recipients. Inspection of sequences from the dually exposed recipient provided evidence of an individual simultaneously infected with two distinct HIV-1 strains, as well as recombination of the two strains in vivo.

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Selected References

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