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. 1995 Jun;69(6):3538–3541. doi: 10.1128/jvi.69.6.3538-3541.1995

Specific inhibition of granzyme B by parainfluenza virus type 3.

S Sieg 1, L Xia 1, Y Huang 1, D Kaplan 1
PMCID: PMC189067  PMID: 7745701

Abstract

T-cell-mediated cytotoxicity is an important means of defense against viral pathogens; however, several viruses possess mechanisms to disrupt cytotoxicity, thereby allowing them to avoid immune clearance. These viruses have been shown to inhibit cytotoxicity by interfering with the capacity of T lymphocytes to specifically recognize infected cells. An alternative mechanism for virally induced cytotoxic dysfunction is identified in this report. We show that parainfluenza virus type 3, a negative-stranded RNA virus, can inhibit cytotoxicity by causing a defect in the cytotoxic effector apparatus. This defect is identified as a selective inhibition of granzyme B mRNA.

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Selected References

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