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. 1995 Jun;69(6):3639–3646. doi: 10.1128/jvi.69.6.3639-3646.1995

Nucleotide sequence of feline immunodeficiency virus: classification of Japanese isolates into two subtypes which are distinct from non-Japanese subtypes.

S Kakinuma 1, K Motokawa 1, T Hohdatsu 1, J K Yamamoto 1, H Koyama 1, H Hashimoto 1
PMCID: PMC189079  PMID: 7745712

Abstract

Seven isolates of feline immunodeficiency virus (FIV), Shizuoka, Yokohama, Sendai-1, Sendai-2, Fukuoka, Aomori-1, and Aomori-2, were isolated from FIV-seropositive domestic cats in Japan, and their proviral DNAs were amplified by PCR. The nucleotide sequences of their env and gag genes were determined and compared with those of previously described isolates: U.S. and European isolates and one Japanese isolate, TM2. Phylogenetic analyses of complete env gene sequences demonstrate that worldwide isolates are classified into three subtypes: Japanese TM2, Japanese Shizuoka, and non-Japanese subtypes (U.S. and European isolates), with 20% amino acid distances from each other. This pattern indicates that an evolutionary radiation of these three subtypes of FIV occurred at approximately the same time. The sequence data of gag genes also confirmed these results. Furthermore, the Sendai-1 isolate was identified as an imported FIV isolate.

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Selected References

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  1. Egberink H., Horzinek M. C. Animal immunodeficiency viruses. Vet Microbiol. 1992 Nov;33(1-4):311–331. doi: 10.1016/0378-1135(92)90059-3. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Gardner M. B. Simian and feline immunodeficiency viruses: animal lentivirus models for evaluation of AIDS vaccines and antiviral agents. Antiviral Res. 1991 May;15(4):267–286. doi: 10.1016/0166-3542(91)90009-g. [DOI] [PubMed] [Google Scholar]
  3. Greene W. K., Meers J., Chadwick B., Carnegie P. R., Robinson W. F. Nucleotide sequences of Australian isolates of the feline immunodeficiency virus: comparison with other feline lentiviruses. Arch Virol. 1993;132(3-4):369–379. doi: 10.1007/BF01309546. [DOI] [PubMed] [Google Scholar]
  4. Greene W. K., Meers J., del Fierro G., Carnegie P. R., Robinson W. F. Extensive sequence variation of feline immunodeficiency virus env genes in isolates from naturally infected cats. Arch Virol. 1993;133(1-2):51–62. doi: 10.1007/BF01309743. [DOI] [PubMed] [Google Scholar]
  5. Higgins D. G., Bleasby A. J., Fuchs R. CLUSTAL V: improved software for multiple sequence alignment. Comput Appl Biosci. 1992 Apr;8(2):189–191. doi: 10.1093/bioinformatics/8.2.189. [DOI] [PubMed] [Google Scholar]
  6. Hohdatsu T., Pu R., Torres B. A., Trujillo S., Gardner M. B., Yamamoto J. K. Passive antibody protection of cats against feline immunodeficiency virus infection. J Virol. 1993 Apr;67(4):2344–2348. doi: 10.1128/jvi.67.4.2344-2348.1993. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Hohdatsu T., Yamada M., Okada M., Fukasawa M., Watanabe K., Ogasawara T., Takagi M., Aizawa C., Hayami M., Koyama H. Detection of feline immunodeficiency proviral DNA in peripheral blood lymphocytes by the polymerase chain reaction. Vet Microbiol. 1992 Feb;30(2-3):113–123. doi: 10.1016/0378-1135(92)90107-5. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Ishida T., Washizu T., Toriyabe K., Motoyoshi S., Tomoda I., Pedersen N. C. Feline immunodeficiency virus infection in cats of Japan. J Am Vet Med Assoc. 1989 Jan 15;194(2):221–225. [PubMed] [Google Scholar]
  9. Jarrett O. Vaccination against feline retroviruses. Dev Biol Stand. 1990;72:185–188. [PubMed] [Google Scholar]
  10. Lombardi S., Garzelli C., La Rosa C., Zaccaro L., Specter S., Malvaldi G., Tozzini F., Esposito F., Bendinelli M. Identification of a linear neutralization site within the third variable region of the feline immunodeficiency virus envelope. J Virol. 1993 Aug;67(8):4742–4749. doi: 10.1128/jvi.67.8.4742-4749.1993. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Maki N., Miyazawa T., Fukasawa M., Hasegawa A., Hayami M., Miki K., Mikami T. Molecular characterization and heterogeneity of feline immunodeficiency virus isolates. Arch Virol. 1992;123(1-2):29–45. doi: 10.1007/BF01317136. [DOI] [PubMed] [Google Scholar]
  12. Miyazawa T., Fukasawa M., Hasegawa A., Maki N., Ikuta K., Takahashi E., Hayami M., Mikami T. Molecular cloning of a novel isolate of feline immunodeficiency virus biologically and genetically different from the original U.S. isolate. J Virol. 1991 Mar;65(3):1572–1577. doi: 10.1128/jvi.65.3.1572-1577.1991. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Morikawa S., Lutz H., Aubert A., Bishop D. H. Identification of conserved and variable regions in the envelope glycoprotein sequences of two feline immunodeficiency viruses isolated in Zurich, Switzerland. Virus Res. 1991 Sep;21(1):53–63. doi: 10.1016/0168-1702(91)90071-3. [DOI] [PubMed] [Google Scholar]
  14. Okada S., Pu R., Young E., Stoffs W. V., Yamamoto J. K. Superinfection of cats with feline immunodeficiency virus subtypes A and B. AIDS Res Hum Retroviruses. 1994 Dec;10(12):1739–1746. doi: 10.1089/aid.1994.10.1739. [DOI] [PubMed] [Google Scholar]
  15. Olmsted R. A., Hirsch V. M., Purcell R. H., Johnson P. R. Nucleotide sequence analysis of feline immunodeficiency virus: genome organization and relationship to other lentiviruses. Proc Natl Acad Sci U S A. 1989 Oct;86(20):8088–8092. doi: 10.1073/pnas.86.20.8088. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Olmsted R. A., Langley R., Roelke M. E., Goeken R. M., Adger-Johnson D., Goff J. P., Albert J. P., Packer C., Laurenson M. K., Caro T. M. Worldwide prevalence of lentivirus infection in wild feline species: epidemiologic and phylogenetic aspects. J Virol. 1992 Oct;66(10):6008–6018. doi: 10.1128/jvi.66.10.6008-6018.1992. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Pancino G., Fossati I., Chappey C., Castelot S., Hurtrel B., Moraillon A., Klatzmann D., Sonigo P. Structure and variations of feline immunodeficiency virus envelope glycoproteins. Virology. 1993 Feb;192(2):659–662. doi: 10.1006/viro.1993.1083. [DOI] [PubMed] [Google Scholar]
  18. Pedersen N. C., Ho E. W., Brown M. L., Yamamoto J. K. Isolation of a T-lymphotropic virus from domestic cats with an immunodeficiency-like syndrome. Science. 1987 Feb 13;235(4790):790–793. doi: 10.1126/science.3643650. [DOI] [PubMed] [Google Scholar]
  19. Pedersen N. C., Yamamoto J. K., Ishida T., Hansen H. Feline immunodeficiency virus infection. Vet Immunol Immunopathol. 1989 May;21(1):111–129. doi: 10.1016/0165-2427(89)90134-7. [DOI] [PubMed] [Google Scholar]
  20. Phillips T. R., Talbott R. L., Lamont C., Muir S., Lovelace K., Elder J. H. Comparison of two host cell range variants of feline immunodeficiency virus. J Virol. 1990 Oct;64(10):4605–4613. doi: 10.1128/jvi.64.10.4605-4613.1990. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Rigby M. A., Holmes E. C., Pistello M., Mackay A., Brown A. J., Neil J. C. Evolution of structural proteins of feline immunodeficiency virus: molecular epidemiology and evidence of selection for change. J Gen Virol. 1993 Mar;74(Pt 3):425–436. doi: 10.1099/0022-1317-74-3-425. [DOI] [PubMed] [Google Scholar]
  22. Saiki R. K., Bugawan T. L., Horn G. T., Mullis K. B., Erlich H. A. Analysis of enzymatically amplified beta-globin and HLA-DQ alpha DNA with allele-specific oligonucleotide probes. Nature. 1986 Nov 13;324(6093):163–166. doi: 10.1038/324163a0. [DOI] [PubMed] [Google Scholar]
  23. Saitou N., Nei M. The neighbor-joining method: a new method for reconstructing phylogenetic trees. Mol Biol Evol. 1987 Jul;4(4):406–425. doi: 10.1093/oxfordjournals.molbev.a040454. [DOI] [PubMed] [Google Scholar]
  24. Siebelink K. H., Chu I. H., Rimmelzwaan G. F., Weijer K., Osterhaus A. D., Bosch M. L. Isolation and partial characterization of infectious molecular clones of feline immunodeficiency virus obtained directly from bone marrow DNA of a naturally infected cat. J Virol. 1992 Feb;66(2):1091–1097. doi: 10.1128/jvi.66.2.1091-1097.1992. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Siebelink K. H., Rimmelzwaan G. F., Bosch M. L., Meloen R. H., Osterhaus A. D. A single amino acid substitution in hypervariable region 5 of the envelope protein of feline immunodeficiency virus allows escape from virus neutralization. J Virol. 1993 Apr;67(4):2202–2208. doi: 10.1128/jvi.67.4.2202-2208.1993. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. Sodora D. L., Shpaer E. G., Kitchell B. E., Dow S. W., Hoover E. A., Mullins J. I. Identification of three feline immunodeficiency virus (FIV) env gene subtypes and comparison of the FIV and human immunodeficiency virus type 1 evolutionary patterns. J Virol. 1994 Apr;68(4):2230–2238. doi: 10.1128/jvi.68.4.2230-2238.1994. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Talbott R. L., Sparger E. E., Lovelace K. M., Fitch W. M., Pedersen N. C., Luciw P. A., Elder J. H. Nucleotide sequence and genomic organization of feline immunodeficiency virus. Proc Natl Acad Sci U S A. 1989 Aug;86(15):5743–5747. doi: 10.1073/pnas.86.15.5743. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. Yamamoto J. K., Hohdatsu T., Olmsted R. A., Pu R., Louie H., Zochlinski H. A., Acevedo V., Johnson H. M., Soulds G. A., Gardner M. B. Experimental vaccine protection against homologous and heterologous strains of feline immunodeficiency virus. J Virol. 1993 Jan;67(1):601–605. doi: 10.1128/jvi.67.1.601-605.1993. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. Yamamoto J. K., Okuda T., Ackley C. D., Louie H., Pembroke E., Zochlinski H., Munn R. J., Gardner M. B. Experimental vaccine protection against feline immunodeficiency virus. AIDS Res Hum Retroviruses. 1991 Nov;7(11):911–922. doi: 10.1089/aid.1991.7.911. [DOI] [PubMed] [Google Scholar]

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