Skip to main content
PMC home page
Journal of Virology logoLink to Journal of Virology
. 1995 Jul;69(7):3967–3971. doi: 10.1128/jvi.69.7.3967-3971.1995

Major histocompatibility complex class I antigens and the control of viral infections by natural killer cells.

R R Brutkiewicz 1, R M Welsh 1
PMCID: PMC189127  PMID: 7769654

Full Text

The Full Text of this article is available as a PDF (181.7 KB).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Andersson M., Päbo S., Nilsson T., Peterson P. A. Impaired intracellular transport of class I MHC antigens as a possible means for adenoviruses to evade immune surveillance. Cell. 1985 Nov;43(1):215–222. doi: 10.1016/0092-8674(85)90026-1. [DOI] [PubMed] [Google Scholar]
  2. Beersma M. F., Bijlmakers M. J., Ploegh H. L. Human cytomegalovirus down-regulates HLA class I expression by reducing the stability of class I H chains. J Immunol. 1993 Nov 1;151(9):4455–4464. [PubMed] [Google Scholar]
  3. Bezouska K., Yuen C. T., O'Brien J., Childs R. A., Chai W., Lawson A. M., Drbal K., Fiserová A., Pospísil M., Feizi T. Oligosaccharide ligands for NKR-P1 protein activate NK cells and cytotoxicity. Nature. 1994 Nov 10;372(6502):150–157. doi: 10.1038/372150a0. [DOI] [PubMed] [Google Scholar]
  4. Biron C. A., Byron K. S., Sullivan J. L. Severe herpesvirus infections in an adolescent without natural killer cells. N Engl J Med. 1989 Jun 29;320(26):1731–1735. doi: 10.1056/NEJM198906293202605. [DOI] [PubMed] [Google Scholar]
  5. Biron C. A. Cytokines in the generation of immune responses to, and resolution of, virus infection. Curr Opin Immunol. 1994 Aug;6(4):530–538. doi: 10.1016/0952-7915(94)90137-6. [DOI] [PubMed] [Google Scholar]
  6. Biron C. A., Sonnenfeld G., Welsh R. M. Interferon induces natural killer cell blastogenesis in vivo. J Leukoc Biol. 1984 Jan;35(1):31–37. doi: 10.1002/jlb.35.1.31. [DOI] [PubMed] [Google Scholar]
  7. Biron C. A., Welsh R. M. Blastogenesis of natural killer cells during viral infection in vivo. J Immunol. 1982 Dec;129(6):2788–2795. [PubMed] [Google Scholar]
  8. Biron C. A., Young H. A., Kasaian M. T. Interleukin 2-induced proliferation of murine natural killer cells in vivo. J Exp Med. 1990 Jan 1;171(1):173–188. doi: 10.1084/jem.171.1.173. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Brutkiewicz R. R., Klaus S. J., Welsh R. M. Window of vulnerability of vaccinia virus-infected cells to natural killer (NK) cell-mediated cytolysis correlates with enhanced NK cell triggering and is concomitant with a decrease in H-2 class I antigen expression. Nat Immun. 1992 Jul-Aug;11(4):203–214. [PubMed] [Google Scholar]
  10. Bukowski J. F., Welsh R. M. Enhanced susceptibility to cytotoxic T lymphocytes of target cells isolated from virus-infected or interferon-treated mice. J Virol. 1986 Sep;59(3):735–739. doi: 10.1128/jvi.59.3.735-739.1986. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Bukowski J. F., Welsh R. M. Inability of interferon to protect virus-infected cells against lysis by natural killer (NK) cells correlates with NK cell-mediated antiviral effects in vivo. J Immunol. 1985 Nov;135(5):3537–3541. [PubMed] [Google Scholar]
  12. Campbell A. E., Slater J. S. Down-regulation of major histocompatibility complex class I synthesis by murine cytomegalovirus early gene expression. J Virol. 1994 Mar;68(3):1805–1811. doi: 10.1128/jvi.68.3.1805-1811.1994. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Chadwick B. S., Sambhara S. R., Sasakura Y., Miller R. G. Effect of class I MHC binding peptides on recognition by natural killer cells. J Immunol. 1992 Nov 15;149(10):3150–3156. [PubMed] [Google Scholar]
  14. Ciccone E., Pende D., Viale O., Than A., Di Donato C., Orengo A. M., Biassoni R., Verdiani S., Amoroso A., Moretta A. Involvement of HLA class I alleles in natural killer (NK) cell-specific functions: expression of HLA-Cw3 confers selective protection from lysis by alloreactive NK clones displaying a defined specificity (specificity 2). J Exp Med. 1992 Oct 1;176(4):963–971. doi: 10.1084/jem.176.4.963. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Cook J. L., May D. L., Lewis A. M., Jr, Walker T. A. Adenovirus E1A gene induction of susceptibility to lysis by natural killer cells and activated macrophages in infected rodent cells. J Virol. 1987 Nov;61(11):3510–3520. doi: 10.1128/jvi.61.11.3510-3520.1987. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Correa I., Raulet D. H. Binding of diverse peptides to MHC class I molecules inhibits target cell lysis by activated natural killer cells. Immunity. 1995 Jan;2(1):61–71. doi: 10.1016/1074-7613(95)90079-9. [DOI] [PubMed] [Google Scholar]
  17. Daniels B. F., Karlhofer F. M., Seaman W. E., Yokoyama W. M. A natural killer cell receptor specific for a major histocompatibility complex class I molecule. J Exp Med. 1994 Aug 1;180(2):687–692. doi: 10.1084/jem.180.2.687. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Daniels B. F., Nakamura M. C., Rosen S. D., Yokoyama W. M., Seaman W. E. Ly-49A, a receptor for H-2Dd, has a functional carbohydrate recognition domain. Immunity. 1994 Dec;1(9):785–792. doi: 10.1016/s1074-7613(94)80020-0. [DOI] [PubMed] [Google Scholar]
  19. Friedman D. J., Ricciardi R. P. Adenovirus type 12 E1A gene represses accumulation of MHC class I mRNAs at the level of transcription. Virology. 1988 Jul;165(1):303–305. doi: 10.1016/0042-6822(88)90689-7. [DOI] [PubMed] [Google Scholar]
  20. Giorda R., Trucco M. Mouse NKR-P1. A family of genes selectively coexpressed in adherent lymphokine-activated killer cells. J Immunol. 1991 Sep 1;147(5):1701–1708. [PubMed] [Google Scholar]
  21. Hill A. B., Barnett B. C., McMichael A. J., McGeoch D. J. HLA class I molecules are not transported to the cell surface in cells infected with herpes simplex virus types 1 and 2. J Immunol. 1994 Mar 15;152(6):2736–2741. [PubMed] [Google Scholar]
  22. Höglund P., Ohlén C., Carbone E., Franksson L., Ljunggren H. G., Latour A., Koller B., Kärre K. Recognition of beta 2-microglobulin-negative (beta 2m-) T-cell blasts by natural killer cells from normal but not from beta 2m- mice: nonresponsiveness controlled by beta 2m- bone marrow in chimeric mice. Proc Natl Acad Sci U S A. 1991 Nov 15;88(22):10332–10336. doi: 10.1073/pnas.88.22.10332. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Kane K. P. Ly-49 mediates EL4 lymphoma adhesion to isolated class I major histocompatibility complex molecules. J Exp Med. 1994 Mar 1;179(3):1011–1015. doi: 10.1084/jem.179.3.1011. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Karlhofer F. M., Ribaudo R. K., Yokoyama W. M. MHC class I alloantigen specificity of Ly-49+ IL-2-activated natural killer cells. Nature. 1992 Jul 2;358(6381):66–70. doi: 10.1038/358066a0. [DOI] [PubMed] [Google Scholar]
  25. Karupiah G., Blanden R. V., Ramshaw I. A. Interferon gamma is involved in the recovery of athymic nude mice from recombinant vaccinia virus/interleukin 2 infection. J Exp Med. 1990 Nov 1;172(5):1495–1503. doi: 10.1084/jem.172.5.1495. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. Kaufman D. S., Schoon R. A., Leibson P. J. Role for major histocompatibility complex class I in regulating natural killer cell-mediated killing of virus-infected cells. Proc Natl Acad Sci U S A. 1992 Sep 1;89(17):8337–8341. doi: 10.1073/pnas.89.17.8337. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Kiessling R. W., Welsh R. M., Jr Killing of normal cells by activated mouse natural killer cells: evidence for two patterns of genetic regulation of lysis. Int J Cancer. 1980 May 15;25(5):611–615. doi: 10.1002/ijc.2910250510. [DOI] [PubMed] [Google Scholar]
  28. Litwin V., Gumperz J., Parham P., Phillips J. H., Lanier L. L. NKB1: a natural killer cell receptor involved in the recognition of polymorphic HLA-B molecules. J Exp Med. 1994 Aug 1;180(2):537–543. doi: 10.1084/jem.180.2.537. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. Ljunggren H. G., Kärre K. In search of the 'missing self': MHC molecules and NK cell recognition. Immunol Today. 1990 Jul;11(7):237–244. doi: 10.1016/0167-5699(90)90097-s. [DOI] [PubMed] [Google Scholar]
  30. Ljunggren H. G., Sturmhöfel K., Wolpert E., Hämmerling G. J., Kärre K. Transfection of beta 2-microglobulin restores IFN-mediated protection from natural killer cell lysis in YAC-1 lymphoma variants. J Immunol. 1990 Jul 1;145(1):380–386. [PubMed] [Google Scholar]
  31. Malnati M. S., Peruzzi M., Parker K. C., Biddison W. E., Ciccone E., Moretta A., Long E. O. Peptide specificity in the recognition of MHC class I by natural killer cell clones. Science. 1995 Feb 17;267(5200):1016–1018. doi: 10.1126/science.7863326. [DOI] [PubMed] [Google Scholar]
  32. McIntyre K. W., Natuk R. J., Biron C. A., Kase K., Greenberger J., Welsh R. M. Blastogenesis of large granular lymphocytes in nonlymphoid organs. J Leukoc Biol. 1988 Jun;43(6):492–501. doi: 10.1002/jlb.43.6.492. [DOI] [PMC free article] [PubMed] [Google Scholar]
  33. Moretta A., Vitale M., Sivori S., Bottino C., Morelli L., Augugliaro R., Barbaresi M., Pende D., Ciccone E., Lopez-Botet M. Human natural killer cell receptors for HLA-class I molecules. Evidence that the Kp43 (CD94) molecule functions as receptor for HLA-B alleles. J Exp Med. 1994 Aug 1;180(2):545–555. doi: 10.1084/jem.180.2.545. [DOI] [PMC free article] [PubMed] [Google Scholar]
  34. Natuk R. J., Welsh R. M. Accumulation and chemotaxis of natural killer/large granular lymphocytes at sites of virus replication. J Immunol. 1987 Feb 1;138(3):877–883. [PubMed] [Google Scholar]
  35. Ramsay A. J., Ruby J., Ramshaw I. A. A case for cytokines as effector molecules in the resolution of virus infection. Immunol Today. 1993 Apr;14(4):155–157. doi: 10.1016/0167-5699(93)90277-R. [DOI] [PubMed] [Google Scholar]
  36. Rinaldo C. R., Jr Modulation of major histocompatibility complex antigen expression by viral infection. Am J Pathol. 1994 Apr;144(4):637–650. [PMC free article] [PubMed] [Google Scholar]
  37. Routes J. M. Adenovirus E1A inhibits IFN-induced resistance to cytolysis by natural killer cells. J Immunol. 1993 May 15;150(10):4315–4322. [PubMed] [Google Scholar]
  38. Scalzo A. A., Fitzgerald N. A., Wallace C. R., Gibbons A. E., Smart Y. C., Burton R. C., Shellam G. R. The effect of the Cmv-1 resistance gene, which is linked to the natural killer cell gene complex, is mediated by natural killer cells. J Immunol. 1992 Jul 15;149(2):581–589. [PubMed] [Google Scholar]
  39. Scheppler J. A., Nicholson J. K., Swan D. C., Ahmed-Ansari A., McDougal J. S. Down-modulation of MHC-I in a CD4+ T cell line, CEM-E5, after HIV-1 infection. J Immunol. 1989 Nov 1;143(9):2858–2866. [PubMed] [Google Scholar]
  40. Storkus W. J., Dawson J. R. Target structures involved in natural killing (NK): characteristics, distribution, and candidate molecules. Crit Rev Immunol. 1991;10(5):393–416. [PubMed] [Google Scholar]
  41. Storkus W. J., Salter R. D., Alexander J., Ward F. E., Ruiz R. E., Cresswell P., Dawson J. R. Class I-induced resistance to natural killing: identification of nonpermissive residues in HLA-A2. Proc Natl Acad Sci U S A. 1991 Jul 15;88(14):5989–5992. doi: 10.1073/pnas.88.14.5989. [DOI] [PMC free article] [PubMed] [Google Scholar]
  42. Storkus W. J., Salter R. D., Cresswell P., Dawson J. R. Peptide-induced modulation of target cell sensitivity to natural killing. J Immunol. 1992 Aug 15;149(4):1185–1190. [PubMed] [Google Scholar]
  43. Su H. C., Ishikawa R., Biron C. A. Transforming growth factor-beta expression and natural killer cell responses during virus infection of normal, nude, and SCID mice. J Immunol. 1993 Nov 1;151(9):4874–4890. [PubMed] [Google Scholar]
  44. Tay C. H., Welsh R. M., Brutkiewicz R. R. NK cell response to viral infections in beta 2-microglobulin-deficient mice. J Immunol. 1995 Jan 15;154(2):780–789. [PubMed] [Google Scholar]
  45. Trinchieri G. Recognition of major histocompatibility complex class I antigens by natural killer cells. J Exp Med. 1994 Aug 1;180(2):417–421. doi: 10.1084/jem.180.2.417. [DOI] [PMC free article] [PubMed] [Google Scholar]
  46. Trinchieri G., Santoli D. Anti-viral activity induced by culturing lymphocytes with tumor-derived or virus-transformed cells. Enhancement of human natural killer cell activity by interferon and antagonistic inhibition of susceptibility of target cells to lysis. J Exp Med. 1978 May 1;147(5):1314–1333. doi: 10.1084/jem.147.5.1314. [DOI] [PMC free article] [PubMed] [Google Scholar]
  47. Welsh R. M., Jr Cytotoxic cells induced during lymphocytic choriomeningitis virus infection of mice. I. Characterization of natural killer cell induction. J Exp Med. 1978 Jul 1;148(1):163–181. doi: 10.1084/jem.148.1.163. [DOI] [PMC free article] [PubMed] [Google Scholar]
  48. Welsh R. M., Jr, Hallenbeck L. A. Effect of virus infections on target cell susceptibility to natural killer cell-mediated lysis. J Immunol. 1980 May;124(5):2491–2497. [PubMed] [Google Scholar]
  49. Welsh R. M., Jr, Zinkernagel R. M., Hallenbeck L. A. Cytotoxic cells induced during lymphocytic choriomeningitis virus infection of mice. II. "Specificities" of the natural killer cells. J Immunol. 1979 Feb;122(2):475–481. [PubMed] [Google Scholar]
  50. Yogeeswaran G., Fujinami R., Kiessling R., Welsh R. M. Interferon-induced alterations in sialic acid and glycoconjugates of L-929 cells. Virology. 1982 Sep;121(2):363–371. doi: 10.1016/0042-6822(82)90174-x. [DOI] [PubMed] [Google Scholar]
  51. Yokoyama W. M., Ryan J. C., Hunter J. J., Smith H. R., Stark M., Seaman W. E. cDNA cloning of mouse NKR-P1 and genetic linkage with LY-49. Identification of a natural killer cell gene complex on mouse chromosome 6. J Immunol. 1991 Nov 1;147(9):3229–3236. [PubMed] [Google Scholar]
  52. del Val M., Hengel H., Häcker H., Hartlaub U., Ruppert T., Lucin P., Koszinowski U. H. Cytomegalovirus prevents antigen presentation by blocking the transport of peptide-loaded major histocompatibility complex class I molecules into the medial-Golgi compartment. J Exp Med. 1992 Sep 1;176(3):729–738. doi: 10.1084/jem.176.3.729. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Journal of Virology are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES