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. 1997 Oct;41(4):480–486. doi: 10.1136/gut.41.4.480

Incidence of Crohn's disease in Stockholm County 1955-1989

A Lapidus 1, O Bernell 1, G Hellers 1, P Persson 1, R Lofberg 1
PMCID: PMC1891542  PMID: 9391246

Abstract

Aim—To evaluate the incidence of Crohn's disease in Stockholm County between 1955 and 1989. 
Methods—A cohort of 1936 patients with Crohn's disease was retrospectively assembled. Incidence rates and changes in disease distribution were assessed.Results—The mean increase in incidence was 15% (95% confidence intervals 12% to 18%) per five year period with a mean annual incidence rate at 4.6/105 during the last two decades. The mean incidence for the entire study period was similar for men and women. The mean age at diagnosis increased from 25 years in 1960-64 to 32 years in 1985-89, partly because of an increasing proportion of patients aged at least 60 years at diagnosis. The proportion of patients with colonic Crohn's disease at the time of diagnosis increased from 15% to 32% (17% difference; 95% confidence intervals 12% to 23%) whereas the proportion of patients with ileocaecal disease decreased from 58% to 41% (17% difference; 95% confidence intervals 10% to 24%) during the study period. Elderly patients had a higher proportion of small bowel disease and a lower proportion of ileocolonic disease compared with the younger patients.Conclusion—The incidence rate of Crohn's disease in Stockholm has stabilised at 4.6/105 and the proportion of elderly patients has increased during a 35 year period. Colonic Crohn's disease has increased in frequency with a reciprocal decrease in ileocaecal disease. 



Keywords: Crohn's disease; inflammatory bowel disease; incidence; epidemiology

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Figure 1 .

Figure 1

: The age specific incidence rates of Crohn's disease between 1955-59 and 1985-89. The relative risk of Crohn's disease for each five year period is compared with the first period (1955-59).

Figure 2 .

Figure 2

: Age specific indicence rates of Crohn's disease per 105 inhabitants as mean of two 15 year periods (1960-74, thin line; 1975-89, thick line).

Figure 3 .

Figure 3

: Age specific incidence rates of Crohn's disease per 105 inhabitants for different birth cohorts as means of five or 10 year cohorts.

Figure 4 .

Figure 4

: Localisation of disease at diagnosis. Mean proportions of total cases in 1955-64 and 1980-89.

Figure 5 .

Figure 5

: The incidence rates of Crohn's disease between 1955-59 and 1985-89 by localisation of disease at diagnosis. The relative risk of Crohn's disease for each five year period is compared with the first period (1955-59).

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