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. 1997 Dec;41(6):778–784. doi: 10.1136/gut.41.6.778

Alkyl halides, super hydrogen production and the pathogenesis of pneumatosis cystoides coli

T Florin 1
PMCID: PMC1891598  PMID: 9462210

Abstract

Keywords: pneumatosis cystoides coli; chloral hydrate; trichloroethylene; methane; hydrogen

Full Text

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Figure 1 .

Figure 1

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: H2 and CH4 (ppm) in headspace of control faecal cultures. A, Methanogenic cultures (n = 24, four subjects × six cultures). B, Non-methanogenic cultures (n = 18, three subjects × six cultures). Filled circles = CH4 ppm, open circles = H2 ppm. Note different scales for H2. 


Figure 2 .

Figure 2

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: H2 versus alkyl halide (concentration range 1 µM-100 mM). Points are means of normalised measurements at four hours from both methanogenic and non-methanogenic culture experiments (n = 28). Data are expressed as the ratio of H2 (ppm) in alkyl halide-amended cultures to mean H2 (ppm) in unamended control cultures. H2 values were significantly greater than control net H2 for chloral hydrate (closed circles), trichloroethanol (closed squares) ([x]⩾ 10 µM), for trichloroacetic acid (closed triangles) (100 µM ⩽ [x]⩽ 1 mM) and for trichloroethylene (open circles) (100 µM ⩽ [x]⩽ 10 mM). 


Figure 3 .

Figure 3

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: Faecal H2 production by rats exposed to chloral hydrate. Points are mean H2 in headspace of four hour faecal cultures derived from rats exposed to chloral hydrate (⩽0.08 g/kg per day) versus negative controls. *p⩽0.04 for comparisons between chloral and control groups. For the washout period immediately after the end of chloral hydrate treatment, differences between mean H2 of the washout group and the negative control group, or previous chloral group, were not statistically significant for individual days but were so when means were pooled over three days, †p = 0.02 for difference between chloral (day 23) and washout (days 24-30) and *p = 0.05 for difference between washout (days 24-30) and control (days 24-30). 


Selected References

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