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. 1992 Jan;36(1):202–205. doi: 10.1128/aac.36.1.202

The separated enantiomers of 2'-deoxy-3'-thiacytidine (BCH 189) both inhibit human immunodeficiency virus replication in vitro.

J A Coates 1, N Cammack 1, H J Jenkinson 1, I M Mutton 1, B A Pearson 1, R Storer 1, J M Cameron 1, C R Penn 1
PMCID: PMC189255  PMID: 1590690

Abstract

Racemic 2'-deoxy-3'-thiacytidine (BCH 189) is a dideoxycytidine analog having a sulfur atom in place of the 3' carbon. The enantiomers of BCH 189 have been resolved and found to be equipotent in antiviral activity against human immunodeficiency virus types 1 and 2. However, the (-)-enantiomer (3TC) is considerably less cytotoxic than the (+)-enantiomer.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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