Abstract
A virus-host cell system in which human cytomegalovirus-infected human cells are entrapped in agarose plugs has been developed. This model provides an inexpensive method for the in vivo evaluation (with outbred, immunocompetent mice) of antiviral drugs against human viruses such as cytomegalovirus that replicate primarily or only in human cells.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Fong C. K., Cohen S. D., McCormick S., Hsiung G. D. Antiviral effect of 9-(1,3-dihydroxy-2-propoxymethyl)guanine against cytomegalovirus infection in a guinea pig model. Antiviral Res. 1987 Jan;7(1):11–23. doi: 10.1016/0166-3542(87)90035-0. [DOI] [PubMed] [Google Scholar]
- Freitas V. R., Fraser-Smith E. B., Matthews T. R. Increased efficacy of ganciclovir in combination with foscarnet against cytomegalovirus and herpes simplex virus type 2 in vitro and in vivo. Antiviral Res. 1989 Nov;12(4):205–212. doi: 10.1016/0166-3542(89)90030-2. [DOI] [PubMed] [Google Scholar]
- Glasgow L. A., Richards J. T., Kern E. R. Effect of acyclovir treatment on acute and chronic murine cytomegalovirus infection. Am J Med. 1982 Jul 20;73(1A):132–137. doi: 10.1016/0002-9343(82)90078-x. [DOI] [PubMed] [Google Scholar]
- Gorelik E., Ovejera A., Shoemaker R., Jarvis A., Alley M., Duff R., Mayo J., Herberman R., Boyd M. Microencapsulated tumor assay: new short-term assay for in vivo evaluation of the effects of anticancer drugs on human tumor cell lines. Cancer Res. 1987 Nov 1;47(21):5739–5747. [PubMed] [Google Scholar]
- Lucia H. L., Griffith B. P., Hsiung G. D. Effect of acyclovir and phosphonoformate on cytomegalovirus infection in guinea pigs. Intervirology. 1984;21(3):141–149. doi: 10.1159/000149512. [DOI] [PubMed] [Google Scholar]
- McMahon J., Schmid S., Weislow O., Stinson S., Camalier R., Gulakowski R., Shoemaker R., Kiser R., Dykes D., Harrison S. Feasibility of cellular microencapsulation technology for evaluation of anti-human immunodeficiency virus drugs in vivo. J Natl Cancer Inst. 1990 Nov 21;82(22):1761–1765. doi: 10.1093/jnci/82.22.1761. [DOI] [PubMed] [Google Scholar]
- Rubin R. H. The indirect effects of cytomegalovirus infection on the outcome of organ transplantation. JAMA. 1989 Jun 23;261(24):3607–3609. [PubMed] [Google Scholar]
- Wallace J. M., Hannah J. Cytomegalovirus pneumonitis in patients with AIDS. Findings in an autopsy series. Chest. 1987 Aug;92(2):198–203. doi: 10.1378/chest.92.2.198. [DOI] [PubMed] [Google Scholar]