TABLE 6.
Average over replicates of the estimates of the recombination fraction between a DNA marker and a tumor initiator locus (c) and of estimates of penetrances for homozygotes for the tumor allele ΨTT and homozygotes ΨTt
|
n = 200
|
n = 2000
|
|||||
|---|---|---|---|---|---|---|
| c | ΨTT | ΨTt | c | ΨTT | ΨTt | |
| c = 0.00 | 0.000 | 0.501 | 0.000 | 0.000 | 0.500 | 0.000 |
| (0.000) | (0.087) | (0.000) | (0.000) | (0.027) | (0.000) | |
| c = 0.05 | 0.025 | 0.475 | 0.013 | 0.027 | 0.477 | 0.012 |
| (0.032) | (0.089) | (0.016) | (0.020) | (0.035) | (0.010) | |
| c = 0.15 | 0.080 | 0.421 | 0.040 | 0.079 | 0.422 | 0.039 |
| (0.065) | (0.100) | (0.034) | (0.050) | (0.057) | (0.026) | |
The standard deviations of the estimates are in parentheses. The simulated penetrances were ΨTT = 0.50, ΨTt = 0. Family sizes (n) were 200 and 2000.