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. 1995 Aug;69(8):5124–5127. doi: 10.1128/jvi.69.8.5124-5127.1995

Neutralization of feline immunodeficiency virus by polyclonal feline antibody: simultaneous involvement of hypervariable regions 4 and 5 of the surface glycoprotein.

K H Siebelink 1, W Huisman 1, J A Karlas 1, G F Rimmelzwaan 1, M L Bosch 1, A D Osterhaus 1
PMCID: PMC189331  PMID: 7609081

Abstract

Sites involved in antibody-mediated neutralization of feline immunodeficiency virus were mapped by reciprocal exchange of envelope fragments or amino acids between molecular clones of feline immunodeficiency virus with different susceptibilities to neutralization by a polyclonal cat serum. Combinations of mutations within HV-4 or within HV-4 and HV-5 changed the susceptibility of the viruses to neutralizing antibody.

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Selected References

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