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. 1995 Sep;69(9):5787–5790. doi: 10.1128/jvi.69.9.5787-5790.1995

Receptor binding site-deleted foot-and-mouth disease (FMD) virus protects cattle from FMD.

T S McKenna 1, J Lubroth 1, E Rieder 1, B Baxt 1, P W Mason 1
PMCID: PMC189442  PMID: 7637023

Abstract

Binding of foot-and-mouth disease virus (FMDV) to cells requires an arginine-glycine-aspartic acid (RGD) sequence in the capsid protein VP1. We have genetically engineered an FMDV in which these three amino acids have been deleted, producing a virus particle which is unable to bind to cells. Cattle vaccinated with these receptor binding site-deleted virions were protected from disease when challenged with a virulent virus, demonstrating that these RGD-deleted viruses could serve as the basis for foot-and-mouth disease vaccines safer than those currently in use. This strategy may prove useful in the development of vaccines for other viral diseases.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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