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. 1995 Sep;69(9):5821–5823. doi: 10.1128/jvi.69.9.5821-5823.1995

Cyclophilin binding to the human immunodeficiency virus type 1 Gag polyprotein is mimicked by an anti-cyclosporine antibody.

E K Franke 1, B X Chen 1, I Tatsis 1, A Diamanduros 1, B F Erlanger 1, J Luban 1
PMCID: PMC189450  PMID: 7543589

Abstract

Human immunodeficiency virus type 1 is unique among retroviruses in that infectivity requires specific incorporation into virions of the cellular protein cyclophilin A through interactions with the Gag polyprotein. Here we show that monoclonal antibody B11 1.4, which recognizes a cyclophilin-binding epitope on cyclosporine, detects denatured or native human immunodeficiency virus type 1 capsid. B11 1.4 does not recognize the capsids of other retroviruses, and binding is inhibited by cyclosporine or by cyclophilin A.

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Selected References

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