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. 1995 Sep;69(9):5824–5828. doi: 10.1128/jvi.69.9.5824-5828.1995

Induction of macrophage procoagulant activity by murine hepatitis virus strain 3: role of tyrosine phosphorylation.

A P Dackiw 1, K Zakrzewski 1, A B Nathens 1, P Y Cheung 1, R Fingerote 1, G A Levy 1, O D Rotstein 1
PMCID: PMC189451  PMID: 7543590

Abstract

The induction of a unique macrophage procoagulant molecule by murine hepatitis virus strain 3 correlates with the severity of viral hepatitis. The role of tyrosine phosphorylation in the signalling pathway leading to procoagulant expression was studied. Murine hepatitis virus strain 3 initiated a rapid increase in phosphotyrosine accumulation. Tyrosine kinase inhibition precluded this increase and abrogated expression of the virus-induced procoagulant mouse fibrinogen-like protein (musfiblp) gene. These findings suggest that manipulation of this signalling pathway in vivo might represent a novel approach to treating this disease.

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Selected References

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